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dc.contributor.authorRabaza Martinez, Ana Virginiapt_BR
dc.contributor.authorFraga Cotelo, Martínpt_BR
dc.contributor.authorCorbellini, Luis Gustavopt_BR
dc.contributor.authorTurner, Katherine Mary Elizabethpt_BR
dc.contributor.authorRiet-Correa, Franklinpt_BR
dc.contributor.authorEisler, Mark C.pt_BR
dc.date.accessioned2021-03-09T04:41:12Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn2352-7714pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/218503pt_BR
dc.description.abstractCoxiella burnetii is an obligate intracellular zoonotic bacterium that causes Q fever. Ruminants, including cattle, are broadly known to be reservoirs for this bacterium. Since 2006, many research groups have evaluated the herd-level prevalence of C. burnetii in cattle by molecular techniques on composite milk samples. This study explored the global C. burnetii herd-level prevalence from studies done on bovine bulk-tank milk (BTM) samples using PCR-based analysis. Also, moderators were investigated to identify sources of heterogeneity. Databases (CAB Abstracts, Medline via Ovid, PubMed, Web of Science and Google Scholar) were searched for index articles on C. burnetii prevalence in BTM samples by PCR published between January-1973 and November-2018. Numerous studies (1054) were initially identified, from which seventeen original publications were included in the meta-analysis based on the pre-defined selection criteria. These studies comprised 4031 BTM samples from twelve countries. A random-effects model was used because of considerable heterogeneity (I2 = 98%) to estimate the herd-level prevalence of C. burnetii as 37.0%(CI95%25.2–49.5%). The average herd size appeared to account for a high level of the heterogeneity. No other moderators (geographic location, gross national income or notification criteria for Q fever) seemed to be determinant. This systematic evaluation demonstrated a high molecular prevalence of C. burnetii in BTM samples both in European and non-European countries, evidencing a widespread herd-level circulation of this agent in bovine dairy farms around the world. Meta-regression showed herd size as the most relevant moderator with the odds of a BTM sample testing positive doubling with every unit increase.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofOne Health. Amsterdam. Vol. 12 (June 2021), 100208, 9 p.pt_BR
dc.rightsOpen Accessen
dc.subjectQ feveren
dc.subjectPrevalênciapt_BR
dc.subjectCoxiellosisen
dc.subjectCoxiella burnetiipt_BR
dc.subjectMeta-prevalenceen
dc.subjectBovinos de leitept_BR
dc.subjectDiagnostico molecularpt_BR
dc.subjectPCRen
dc.subjectTanque de leitept_BR
dc.subjectIS1111en
dc.subjectRevisão sistemáticapt_BR
dc.titleMolecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds : systematic review and meta-analysispt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001122204pt_BR
dc.type.originEstrangeiropt_BR


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