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dc.contributor.authorSortica, Denise Alvespt_BR
dc.contributor.authorCrispim, Daisypt_BR
dc.contributor.authorBauer, Andrea Carlapt_BR
dc.contributor.authorNique, Pâmela Sachspt_BR
dc.contributor.authorNicoletto, Bruna Bellincantapt_BR
dc.contributor.authorCrestani, Riciéli Pachecopt_BR
dc.contributor.authorStaehler, Jennifer Tassonipt_BR
dc.contributor.authorManfro, Roberto Cerattipt_BR
dc.contributor.authorCanani, Luis Henrique Santospt_BR
dc.date.accessioned2021-02-11T04:10:34Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/217894pt_BR
dc.description.abstractThe identification of risk factors for acute rejection (AR) may lead to strategies to improve success of kidney transplantation. Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides into nucleosides, modulating the purinergic signaling. Some members of the Ectonucleotidase family have been linked to transplant rejection processes. However, the association of Ectonucleotide Pyrophosphatase / Phosphodiesterase 1 (ENPP1) with AR has not yet been evaluated. The aim of this study was to evaluate the association between the K121Q polymorphism of ENPP1 gene and AR in kidney transplant patients. We analyzed 449 subjects without AR and 98 with AR from a retrospective cohort of kidney transplant patients from Southern Brazil. K121Q polymorphism was genotyped using allelic discrimination-real-time PCR. Cox regression analysis was used to evaluate freedom of AR in kidney transplant patients according to genotypes. Q allele frequency was 17.6% in recipients without AR and 21.9% in those with AR (P = 0.209). Genotype frequencies of the K121Q polymorphism were in Hardy-Weinberg equilibrium in non-AR patients (P = 0.70). The Q/Q genotype (recessive model) was associated with AR (HR = 2.83, 95% CI 1.08–7.45; P = 0.034) after adjusting for confounders factors. Our findings suggest a novel association between the ENPP1 121Q/Q genotype and AR in kidney transplant recipients.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPloS one. San Francisco. Vol. 14, no. 7 (July 2019), e0219062, 12 p.pt_BR
dc.rightsOpen Accessen
dc.subjectTransplante de rimpt_BR
dc.subjectRejeição de enxertopt_BR
dc.subjectPolimorfismo genéticopt_BR
dc.titleK121Q polymorphism in the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 gene is associated with acute kidney rejectionpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001120920pt_BR
dc.type.originEstrangeiropt_BR


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