Performance of cystatin c-based equations for estimation of glomerular filtration rate in diabetes patients : a prisma-compliant systematic review and meta-analysis
dc.contributor.author | Cheuiche, Amanda Veiga | pt_BR |
dc.contributor.author | Queiroz, Marina | pt_BR |
dc.contributor.author | Silva, André Luis Ferreira da | pt_BR |
dc.contributor.author | Silveiro, Sandra Pinho | pt_BR |
dc.date.accessioned | 2021-02-09T04:06:59Z | pt_BR |
dc.date.issued | 2019 | pt_BR |
dc.identifier.issn | 2045-2322 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/217801 | pt_BR |
dc.description.abstract | The accuracy of estimated glomerular fltration rate (eGFR) equations in diabetes mellitus (DM) patients has been extensively questioned. We evaluated the performance of cystatin C-based equations alone or in combination with creatinine to estimate GFR in DM patients. A PRISMA-compliant systematic review was performed in the MEDLINE and Embase databases, with “diabetes mellitus” and “cystatin C” as search terms. Studies comparing cystatin C-based eGFR equations with measured GFR (mGFR) in DM patients were eligible. Accuracies P10, P15, P20, and P30 indicated the proportion of eGFR results within 10, 15, 20, and 30% of mGFR. Single-arm meta-analyses were conducted, and the Quality of Diagnostic Accuracy Studies-II tool (QUADAS-2) was applied. Twenty-three studies comprising 7065 participants were included, and 24 equations were analyzed in a broad range of GFRs. Meta-analyses were completed for 10 equations. The mean P30 accuracies of the equations ranged from 41% to 87%, with the highest values found with both CKD-EPI equations. Mean P10-P15 achieved 35% in the best scenario. A sensitivity analysis to evaluate diferent mGFR methods did not change results. In conclusion, cystatin C-based eGFR equations represent measured GFR fairly at best in DM patients, with high variability among the several proposed equations. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Scientific reports. London. Vol. 9 (2019), 1418, 10 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Cistatina C | pt_BR |
dc.subject | Diabetes mellitus | pt_BR |
dc.subject | Revisão sistemática | pt_BR |
dc.subject | Metanálise | pt_BR |
dc.title | Performance of cystatin c-based equations for estimation of glomerular filtration rate in diabetes patients : a prisma-compliant systematic review and meta-analysis | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001120541 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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