Neonatal morphine exposure and maternal deprivation alter nociceptive response and central biomarkers’ levels throughout the life of rats
dc.contributor.author | Oliveira, Carla de | pt_BR |
dc.contributor.author | Ströher, Roberta | pt_BR |
dc.contributor.author | Scarabelot, Vanessa Leal | pt_BR |
dc.contributor.author | Vercelino, Rafael | pt_BR |
dc.contributor.author | Silva, Lisiane Santos da | pt_BR |
dc.contributor.author | Regner, Gabriela Gregory | pt_BR |
dc.contributor.author | Souza, Andressa de | pt_BR |
dc.contributor.author | Silveira, Natália P. | pt_BR |
dc.contributor.author | Torres, Iraci Lucena da Silva | pt_BR |
dc.contributor.author | Caumo, Wolnei | pt_BR |
dc.date.accessioned | 2020-12-19T04:19:37Z | pt_BR |
dc.date.issued | 2020 | pt_BR |
dc.identifier.issn | 1872-7972 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/216736 | pt_BR |
dc.description.abstract | In the present study, we investigated the effect of repeated neonatal morphine exposure and/or maternal deprivation(MD) on the nociceptive response and central biomarkers’ BDNF, IL-1β, and IL-4 levels at postnatal days 16(PND16), 30(PND30), and 60(PND60). At birth, the litters were standardized to contain 8 pups/dam (n = 58). From PND1 to PND10, the pups of the deprived groups were separated daily from their mothers for 3 h and divided into 5 groups: control(C), saline(S), morphine(M), deprived-saline(DS), and deprived-morphine (DM). The pups received subcutaneous injections of saline/morphine (5 μg) in the mid-scapular area between PND8 and PND14. Nociceptive responses were assessed by hot plate(HP) and tail-flick(TFL) tests and biomarker levels by ELISA. Thermal hyperalgesia(HP) was found in all assessments for the M, DS, and DM groups, and a decrease in nociceptive threshold(TFL) was found in the DS group at PND16; M and DM groups at PND30; and M, DS, and DM groups at PND60. There were interactions between treatment/deprivation/timepoint in all central biomarkers’ levels. The current study indicates that neonatal exposure to morphine and MD, which occurs in the pediatric ICU, can alter the nociceptive and neuroinflammatory responses. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Neuroscience letters. Limerick. Vol. 738 (2020), 135350, 8 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Analgesicos opióides | pt_BR |
dc.subject | Opioid | en |
dc.subject | Maternal-separation | en |
dc.subject | Privação materna | pt_BR |
dc.subject | Nociceptividade | pt_BR |
dc.subject | Neonate rats | en |
dc.subject | Nociception | en |
dc.subject | Modelos animais | pt_BR |
dc.title | Neonatal morphine exposure and maternal deprivation alter nociceptive response and central biomarkers’ levels throughout the life of rats | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001119815 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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