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dc.contributor.authorFarias, Áurea Dias dept_BR
dc.contributor.authorEberle, Lucianapt_BR
dc.contributor.authorAmador, Tania Alvespt_BR
dc.contributor.authorDal Pizzol, Tatiane da Silvapt_BR
dc.date.accessioned2020-08-04T03:38:30Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn2523-3106pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/212563pt_BR
dc.description.abstractBackground: Duloxetine and amitriptyline are antidepressants used in the treatment of fibromyalgia. In published systematic reviews, there is no agreement about which drug is more effective and safer. This study aimed to compare evidence of the efficacy and safety of duloxetine compared with amitriptyline in the treatment of adult patients with fibromyalgia. This work contributes to guiding clinicians on the use of duloxetine or amitriptyline for the treatment of fibromyalgia and provides information for public health decision-makers. Methods: Overview of systematic reviews of clinical trials comparing duloxetine and amitriptyline in the treatment of fibromyalgia. The reviews were screened in Cochrane, PubMed, EMBASE, and SRDR with no restrictions on language and year of publication, considering that the research was conducted in July 2018 and updated until May 2020. The selection was based on the following criteria: adult patients with a diagnosis of fibromyalgia treated with duloxetine or amitriptyline, comparing the efficacy and safety in pain, fatigue, sleep, and mood disorder symptoms and quality of life, in addition to the acceptability of these antidepressants. The methodological quality and strength of evidence were assessed using the AMSTAR and GRADE instruments. Results: Eight systematic reviews were selected. Amitriptyline had low evidence for pain, moderate evidence for sleep and fatigue, and high evidence for quality of life. Duloxetine had high quality of evidence in patients with mood disorders. With low evidence, duloxetine has higher acceptability, but is safer in older patients, while amitriptyline is safer for non-elderly individuals. Conclusion: Both antidepressants are effective in the treatment of fibromyalgia, differing according to the patient’s symptoms and profile.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofAdvances in rheumatology. [London]. Vol. 60 (2020), 35 [9 p.]pt_BR
dc.rightsOpen Accessen
dc.subjectFibromyalgiaen
dc.subjectFibromialgiapt_BR
dc.subjectDuloxetineen
dc.subjectDuloxetinapt_BR
dc.subjectAmitriptilinapt_BR
dc.subjectAmitriptylineen
dc.subjectSystematic reviewen
dc.subjectRevisão sistemáticapt_BR
dc.subjectOverviewen
dc.titleComparing the efficacy and safety of duloxetine and amitriptyline in the treatment of fibromyalgia : overview of systematic reviewspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001116312pt_BR
dc.type.originEstrangeiropt_BR


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