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Interference of propylene glycol with the hole-board test
dc.contributor.author | Silva, Adriana Lourenço da | pt_BR |
dc.contributor.author | Elisabetsky, Elaine | pt_BR |
dc.date.accessioned | 2010-04-24T04:15:42Z | pt_BR |
dc.date.issued | 2001 | pt_BR |
dc.identifier.issn | 0100-879X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/21203 | pt_BR |
dc.description.abstract | Experimental drugs and/or plant extracts are often dissolved in solvents, including propylene glycol. Nevertheless, there is evidence for psychoactive properties of this alcohol. In this study we found that in the hole-board test 10% propylene glycol did not modify the headdipping behavior. However, 30% propylene glycol induced an increase in the number of head-dips (46.92 ± 2.37 compared to 33.83 ± 4.39, P<0.05, ANOVA/Student-Newman-Keuls), an effect comparable to that obtained with 0.5 mg/kg diazepam (from 33.83 ± 4.39 to 54 ± 3.8, P<0.01, ANOVA/Student-Newman-Keuls). These results demonstrate that 30% propylene glycol has significant anxiolytic effects in this model and therefore cannot be used as an innocuous solvent. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Revista brasileira de pesquisas médicas e biológicas = Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 4 (Apr. 2001), p. 545-547 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Screening | en |
dc.subject | Farmacologia clínica | pt_BR |
dc.subject | Anxiolytic drugs | en |
dc.subject | Propylene glycol | en |
dc.subject | Diazepam | en |
dc.subject | Solvents | en |
dc.subject | Hole-board | en |
dc.title | Interference of propylene glycol with the hole-board test | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000576295 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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