Frequency of CCR5delta32 in brazilian populations
dc.contributor.author | Vargas, Andréia Escosteguy | pt_BR |
dc.contributor.author | Marrero, Andrea Rita | pt_BR |
dc.contributor.author | Salzano, Francisco Mauro | pt_BR |
dc.contributor.author | Bortolini, Maria Cátira | pt_BR |
dc.contributor.author | Chies, Jose Artur Bogo | pt_BR |
dc.date.accessioned | 2010-04-24T04:15:41Z | pt_BR |
dc.date.issued | 2006 | pt_BR |
dc.identifier.issn | 0100-879X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/21200 | pt_BR |
dc.description.abstract | A sample of 103 randomly chosen healthy individuals from Alegrete, RS, Brazil, was tested for the CCR5Δ32 allele, which is known to influence susceptibility to HIV-1 infection. The CCR5Δ32 allele was identified by PCR amplification using specific primers flanking the region of deletion, followed by electrophoresis on a 3% agarose gel. The data obtained were compared to those reported for other populations and interpreted in terms of Brazilian history. The individuals studied came from a highly admixed population. Most of them were identified as white (N = 59), while blacks and browns (mulattoes) were N = 13 and N = 31, respectively. The observed frequencies, considering the white, black and brown samples (6.8, 3.8, and 6.4%, respectively), suggest an important European parental contribution, even in populations identified as black and brown. However, in Brazil as a whole, this allele shows gradients indicating a relatively good correlation with the classification based on skin color and other physical traits, used here to define major Brazilian population groups. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 39, n. 3 (Mar. 2006), p. 321-325 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Genética de populações | pt_BR |
dc.subject | CCR5 | en |
dc.subject | Chemokine receptors | en |
dc.subject | Brazilian population | en |
dc.subject | Gene flow | en |
dc.title | Frequency of CCR5delta32 in brazilian populations | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000559818 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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