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Lipid peroxidation and total radical-trapping potential of the lungs of rats submitted to chronic and sub-chronic stress
dc.contributor.author | Torres, Ronaldo Lopes | pt_BR |
dc.contributor.author | Gamaro, Giovana Duzzo | pt_BR |
dc.contributor.author | Torres, Iraci Lucena da Silva | pt_BR |
dc.contributor.author | Fontella, Fernanda Urruth | pt_BR |
dc.contributor.author | Silveira, Patrícia Pelufo | pt_BR |
dc.contributor.author | Moreira, Juliano Soares Rabello | pt_BR |
dc.contributor.author | Lacerda, Mariane Americo | pt_BR |
dc.contributor.author | Amoretti, José Ricardo Luz | pt_BR |
dc.contributor.author | Rech, Daniel | pt_BR |
dc.contributor.author | Dalmaz, Carla | pt_BR |
dc.contributor.author | Bello, Antonio Andrea | pt_BR |
dc.date.accessioned | 2010-04-24T04:15:37Z | pt_BR |
dc.date.issued | 2004 | pt_BR |
dc.identifier.issn | 0100-879X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/21180 | pt_BR |
dc.description.abstract | Exposure to stress induces a cluster of physiological and behavioral changes in an effort to maintain the homeostasis of the organism. Long-term exposure to stress, however, has detrimental effects on several cell functions such as the impairment of antioxidant defenses leading to oxidative damage. Oxidative stress is a central feature of many diseases. The lungs are particularly susceptible to lesions by free radicals and pulmonary antioxidant defenses are extensively distributed and include both enzymatic and non-enzymatic systems. The aim of the present study was to determine lipid peroxidation and total radical-trapping potential (TRAP) changes in lungs of rats submitted to different models of chronic stress. Adult male Wistar rats weighing 180-230 g were submitted to different stressors (variable stress, N = 7) or repeated restraint stress for 15 (N = 10) or 40 days (N = 6) and compared to control groups (N = 10 each). Lipid peroxidation levels were assessed by thiobarbituric acid reactive substances (TBARS), and TRAP was measured by the decrease in luminescence using the 2- 2'-azo-bis(2-amidinopropane)-luminol system. Chronic variable stress induced a 51% increase in oxidative stress in lungs (control group: 0.037 ± 0.002; variable stress: 0.056 ± 0.007, P < 0.01). No difference in TBARS was observed after chronic restraint stress, but a significant 57% increase in TRAP was presented by the group repeatedly restrained for 15 days (control group: 2.48 ± 0.42; stressed: 3.65 ± 0.16, P < 0.05). We conclude that different stressors induce different effects on the oxidative status of the organism. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 37, no. 2 (Feb. 2004), p. 185-192 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Bioquímica | pt_BR |
dc.subject | Stress | en |
dc.subject | TBARS | en |
dc.subject | TRAP | en |
dc.subject | Free radicals | en |
dc.subject | Lungs | en |
dc.subject | Oxidative stress | en |
dc.title | Lipid peroxidation and total radical-trapping potential of the lungs of rats submitted to chronic and sub-chronic stress | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000503743 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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