Mostrar el registro sencillo del ítem

dc.contributor.authorD'Avila, Katia de Angelis Lobopt_BR
dc.contributor.authorOliveira, Álvaro Reischak dept_BR
dc.contributor.authorDall'Ago, Pedropt_BR
dc.contributor.authorPeixoto, Lívia Rodrigues Araújopt_BR
dc.contributor.authorGadonski, Giovanipt_BR
dc.contributor.authorLacchini, Silviapt_BR
dc.contributor.authorPiedras, Tania Regina Gattelli Fernandespt_BR
dc.contributor.authorIrigoyen, Maria Claudia Costapt_BR
dc.date.accessioned2010-04-24T04:15:31Zpt_BR
dc.date.issued2000pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21155pt_BR
dc.description.abstractSeveral investigators have demonstrated that diabetes is associated with autonomic and myocardial dysfunction. Exercise training is an efficient non-pharmacological treatment for cardiac and metabolic diseases. The aim of the present study was to investigate the effects of exercise training on hemodynamic and autonomic diabetic dysfunction. After 1 week of diabetes induction (streptozotocin, 50 mg/kg, iv), male Wistar rats (222 ± 5 g, N = 18) were submitted to exercise training for 10 weeks on a treadmill. Arterial pressure signals were obtained and processed with a data acquisition system. Autonomic function and intrinsic heart rate were studied by injecting methylatropine and propranolol. Left ventricular function was assessed in hearts perfused in vitro by the Langendorff technique. Diabetes (D) bradycardia and hypotension (D: 279 ± 9 bpm and 91 ± 4 mmHg vs 315 ± 11 bpm and 111 ± 4 mmHg in controls, C) were attenuated by training (TD: 305 ± 7 bpm and 100 ± 4 mmHg). Vagal tonus was decreased in the diabetic groups and sympathetic tonus was similar in all animals. Intrinsic heart rate was lower in D (284 ± 11 bpm) compared to C and TD (390 ± 8 and 342 ± 14 bpm, respectively). Peak systolic pressure developed at different pressures was similar for all groups, but +dP/dt max was decreased and -dP/dt max was increased in D. In conclusion, exercise training reversed hypotension and bradycardia and improved myocardial function in diabetic rats. These changes represent an adaptive response to the demands of training, supporting a positive role of physical activity in the management of diabetes.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 33, no. 6 (June 2000), p. 635-641pt_BR
dc.rightsOpen Accessen
dc.subjectExperimental diabetesen
dc.subjectDiabete : Frequencia cardiaca : Pressao arterial : Ratospt_BR
dc.subjectExercise trainingen
dc.subjectExercício físicopt_BR
dc.subjectFisiologiapt_BR
dc.subjectArterial pressureen
dc.subjectAutonomic controlen
dc.subjectMyocardial contractilityen
dc.titleEffects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000295587pt_BR
dc.type.originNacionalpt_BR


Ficheros en el ítem

Thumbnail
   

Este ítem está licenciado en la Creative Commons License

Mostrar el registro sencillo del ítem