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dc.contributor.authorRöhsig, Liane Marisept_BR
dc.contributor.authorDamin, Daniel de Carvalhopt_BR
dc.contributor.authorStefani, Stephen Doralpt_BR
dc.contributor.authorCastro Junior, Cláudio Galvão dept_BR
dc.contributor.authorRoisenberg, Israelpt_BR
dc.contributor.authorSchwartsmann, Gilbertopt_BR
dc.date.accessioned2010-04-24T04:15:30Zpt_BR
dc.date.issued2001pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21151pt_BR
dc.description.abstractVon Willebrand factor (vWF) is a protein that mediates platelet adherence to the subendothelium during primary hemostasis. High plasma vWF concentrations have been reported in patients with various types of cancer, such as head and neck, laryngeal and prostatic cancer, probably representing an acute phase reactant. In the present study we determined the plasma levels of vWF antigen (vWF:Ag) by quantitative immunoelectrophoresis in 128 female patients with breast cancer as well as in 47 women with benign breast disease and in 27 healthy female controls. The levels of vWF:Ag were 170.7 ± 78 U/dl in patients with cancer, 148.4 ± 59 U/dl in patients with benign disease and 130.6 ± 45 U/dl in controls (P<0.005). We also detected a significant increase in the levels of vWF:Ag (P<0.0001) in patients with advanced stages of the disease (stage IV = 263.3 ± 113 U/dl, stage IIIB = 194.0 ± 44 U/dl) as compared to those with earlier stages of the disease (stage I = 155.3 ± 65 U/dl, stage IIA = 146.9 ± 75 U/dl). In conclusion, vWF levels were increased in plasma of patients with malignant breast disease, and these levels correlated with tumor progression.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 9 (Sept. 2001), p. 1125-1129pt_BR
dc.rightsOpen Accessen
dc.subjectVon Willebrand factoren
dc.subjectFator de von Willebrandpt_BR
dc.subjectBreast canceren
dc.subjectNeoplasias da mamapt_BR
dc.subjectSegunda neoplasia primáriapt_BR
dc.subjectMalignancyen
dc.titleVon Willebrand factor antigen levels in plasma of patients with malignant breast diseasept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000387239pt_BR
dc.type.originNacionalpt_BR


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