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dc.contributor.authorDalcin, Paulo de Tarso Rothpt_BR
dc.contributor.authorMenna Barreto, Sérgio Saldanhapt_BR
dc.contributor.authorCunha, Renato Duarte dapt_BR
dc.contributor.authorXavier, Ricardo Machadopt_BR
dc.contributor.authorBrenol, João Carlos Tavarespt_BR
dc.contributor.authorMarroni, Belmonte Juarezpt_BR
dc.date.accessioned2010-04-24T04:15:28Zpt_BR
dc.date.issued2002pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21143pt_BR
dc.description.abstractThe early demonstration of lung involvement in systemic lupus erythematosus (SLE) patients is a difficult but important task. In the present study we attempted to identify abnormalities in pulmonary clearance of 99mTc-DTPA in SLE, correlating their clearance data with clinical findings and disease activity. Forty-six consecutive SLE patients with and without active disease (LACC score) and 30 normal volunteers were studied. All subjects were submitted to pulmonary scintigraphy with 99mTc-DTPA to evaluate the pulmonary clearance, and to a chest X-ray, and SLE patients were submitted to tests of disease activity, spirometry, arterial blood gases and tests to assess acute-phase proteins. Pulmonary clearance was faster in SLE patients with active disease when compared to normal controls [half-life of 67.04 min (51.52-82.55 min) in active SLE versus 85.87 min (78.85- 92.87 min) in controls, P<0.05] and there was a higher frequency of abnormal clearance rates in patients with active disease (11 of 26 patients, 42.3%) when compared with SLE patients without disease activity (2 of 20 patients, 10%) (P = 0.04). A significant correlation was observed between the clearance rates and cough (P<0.05), but not between the clearance rates and dyspnea symptoms or radiological findings, duration of SLE disease, antinuclear antibody titers and patterns, C-reactive protein or anti-double stranded DNA antibodies. We conclude that the pulmonary clearance of 99mTc-DTPA is increased in SLE patients with active disease.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 35, no. 6 (June 2002), p. 663-668pt_BR
dc.rightsOpen Accessen
dc.subjectLupus eritematoso sistêmicopt_BR
dc.subjectPulmonary epithelial permeabilityen
dc.subjectLung clearanceen
dc.subjectPulmãopt_BR
dc.subjectTechnetium-99m-labeled diethylenetriamine pentaacetic aciden
dc.subjectFluxo sanguíneo regionalpt_BR
dc.subjectPermeabilidade capilarpt_BR
dc.subjectSystemic lupus erythematosusen
dc.subjectEstudos de casos e controlespt_BR
dc.titleLung clearance of 99m TC-DTPA in systemic lupus erythematosuspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000329176pt_BR
dc.type.originNacionalpt_BR


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