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dc.contributor.authorZim, Maria do Carmo Appelpt_BR
dc.contributor.authorSilveira, Themis Reverbel dapt_BR
dc.contributor.authorSchwartsmann, Gilbertopt_BR
dc.contributor.authorCerski, Carlos Thadeu Schmidtpt_BR
dc.contributor.authorMotta, Arnaldo Alves dapt_BR
dc.date.accessioned2010-04-24T04:15:23Zpt_BR
dc.date.issued2002pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21117pt_BR
dc.description.abstractFew data are available in the literature regarding the effect of pentosan polysulfate (PPS) on normal and fibrotic rat livers. In addition, the combination of PPS and carbon tetrachloride (CCl4) has not been studied so far. The objective of this study was to assess the effect of PPS on rat livers treated or not with CCl4 for the induction of liver fibrosis. The study consisted of four stages: 1) hepatic fibrosis induction with CCl4 (N = 36 rats); 2) evaluation of the effect of PPS on CCl4- induced hepatic fibrosis (N = 36 rats); 3) evaluation of the effect of higher doses of PPS in combination with CCl4 (N = 50 rats); 4) evaluation of the presence of an enzymatic inductor effect by PPS (N = 18 rats) using the sodium pentobarbital test which indirectly evaluates hepatic microsomal enzyme activity in vivo. Adult (60 to 70 days) male Wistar rats weighing 180 to 220 g were used. All animals receiving 0.5 ml 8% CCl4 (N = 36) developed hepatic fibrosis, and after 8 weeks they also developed cirrhosis. No delay or prevention of hepatic fibrosis was observed with the administration of 5 mg/kg PPS (N = 8) and 1 mg/kg PPS (N = 8) 1 h after the administration of CCl4, but the increased hepatotoxicity resulting from the combination of the two substances caused massive hepatic necrosis in most rats (N = 45). PPS (40 mg/kg) alone caused hepatic congestion only after 8 weeks, but massive hepatic necrosis was again observed in association with 0.5 ml CCl4 after 1 to 4 weeks of treatment. Unexpectedly, sleeping time increased with time of PPS administration (1, 2, or 3 weeks). This suggests that PPS does not function as an activator of the hepatic microsomal enzymatic system. Further studies are necessary in order to clarify the unexpected increase in hepatotoxicity caused by the combination of CCl4 and high doses of PPS, which results in massive hepatic necrosis.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 35, no. 11 (Nov. 2002), p. 1339-1346pt_BR
dc.rightsOpen Accessen
dc.subjectCirrhosisen
dc.subjectFígadopt_BR
dc.subjectFibrogenesisen
dc.subjectCirrose hepáticapt_BR
dc.subjectHepatic necrosisen
dc.subjectModelos animais de doençaspt_BR
dc.subjectRatospt_BR
dc.subjectPentosan polysulfateen
dc.subjectCarbon tetrachlorideen
dc.subjectPoliéster sulfúrico de pentosanapt_BR
dc.subjectTetracloreto de carbonopt_BR
dc.titlePotentiation of carbon tetrachloride hepatotoxicity by pentosan polysulfate in ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000353596pt_BR
dc.type.originNacionalpt_BR


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