Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
dc.contributor.author | Furlanetto, Tania Weber | pt_BR |
dc.contributor.author | Nunes Junior, R. B. | pt_BR |
dc.contributor.author | Sopelsa, Andreia Maria Ida | pt_BR |
dc.contributor.author | Maciel, R.M.B. | pt_BR |
dc.date.accessioned | 2010-04-24T04:15:22Z | pt_BR |
dc.date.issued | 2001 | pt_BR |
dc.identifier.issn | 0100-879X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/21115 | pt_BR |
dc.description.abstract | Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 2 (Feb. 2001), p. 259-263 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Estradiol | pt_BR |
dc.subject | Iodide uptake | en |
dc.subject | Estradiol | en |
dc.subject | Iodetos | pt_BR |
dc.subject | Thyroid | en |
dc.subject | Modelos animais | pt_BR |
dc.subject | Follicular cells | en |
dc.title | Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000301594 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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