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dc.contributor.authorVeras, Kleyton Santospt_BR
dc.contributor.authorFachel, Flávia Nathiely Silveirapt_BR
dc.contributor.authorPittol, Vanessapt_BR
dc.contributor.authorGarcia, Keth Ribeiropt_BR
dc.contributor.authorBassani, Valquiria Linckpt_BR
dc.contributor.authorSantos, Venina dospt_BR
dc.contributor.authorHenriques, Amelia Teresinhapt_BR
dc.contributor.authorTeixeira, Helder Ferreirapt_BR
dc.contributor.authorKoester, Leticia Schererpt_BR
dc.date.accessioned2020-03-04T04:20:21Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn1319-0164pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/206428pt_BR
dc.description.abstractRosmarinic acid (RA) is a phenolic compound that presents well-documented anti-inflammatory, antioxidant and antitumor activities, and based on its pharmacological potential and poor bioavailability, several solid dosage forms have been developed to RA delivery. Therefore, in literature, there are no reports about RA compatibility with excipients. In this regard, the aim of the present study was to evaluate, for the first time, the compatibility of RA with excipients commonly used in solid dosage forms at a 1:1 (RA: excipient) ratio using differential scanning calorimetry (DSC), thermogravimetry (TG), Fourier-transform infrared (FTIR), solid-state nuclear magnetic resonance (ssNMR), and isothermal stress testing (IST) coupled with liquid chromatography (LC). The excipients selected were hydroxypropyl methylcellulose (HPMC), microcrystalline cellulose (MCC), lactose monohydrate (LAC), polyvinylpyrrolidone (PVP), talc (TALC), croscarmellose sodium (CCS), and magnesium stearate (MgSTE). According to DSC results, physical interactions were found between RA and HPMC, LAC, CCS, and MgSTE. The TG analyses confirmed the physical interactions and suggested chemical incompatibility. FTIR revealed physical interaction of RA with TALC and MgSTE and the ssNMR confirmed the physical interaction showed by FTIR and excluded the presence of chemical incompatibility. By IST, the greatest loss of RA content was found to CCS and MgSTE (>15%), demonstrating chemical incompatibilities with RA. High temperatures used in DSC and TG analyses could be responsible for incompatibilities in binary mixtures (BMs) with HPMC and LAC, while temperature above 25 C and presence of water were factors that promote incompatibilities in BMs with CCS and MgSTE. Overall results demonstrate that RA was compatible with MCC and PVP.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofSaudi Pharmaceutical Journal. Riad (Arábia Saudita). Vol. 27, no. 8 (Dec. 2019), p. 1138-1145pt_BR
dc.rightsOpen Accessen
dc.subjectRosmarinic aciden
dc.subjectFarmáciapt_BR
dc.subjectÁcido rosmarínicopt_BR
dc.subjectExcipienten
dc.subjectCompatibilityen
dc.subjectTGen
dc.subjectssNMRen
dc.subjectISTen
dc.titleCompatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniquespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001110276pt_BR
dc.type.originEstrangeiropt_BR


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