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dc.contributor.authorMelo, Marineide Gonçalves dept_BR
dc.contributor.authorVarella, Ivana Rosângela dos Santospt_BR
dc.contributor.authorGorbach, Pamina M.pt_BR
dc.contributor.authorSprinz, Eduardopt_BR
dc.contributor.authorSantos, Breno Riegel dospt_BR
dc.contributor.authorRocha, Tauí de Melopt_BR
dc.contributor.authorMoesch, Mariana Riegel de Pádua Simonpt_BR
dc.contributor.authorAzambuja, Marcelo Almeidapt_BR
dc.contributor.authorLira, Ritapt_BR
dc.contributor.authorSeter, Maria Cristina Chavespt_BR
dc.contributor.authorBaker, Zoëpt_BR
dc.contributor.authorKerin, Tarapt_BR
dc.contributor.authorNielsen-Saines, Karin A.pt_BR
dc.date.accessioned2020-02-22T04:21:53Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/206229pt_BR
dc.description.abstractBackground: An undetectable serum HIV-1 load is key to effectiveness of antiretroviral (ARV) therapy, which depends on adherence to treatment. We evaluated factors possibly associated with ARV adherence and virologic response in HIV-infected heterosexual individuals. Methods: A cross-sectional study was conducted in 200 HIV-1 serodiscordant couples and 100 unpartnered individuals receiving ARV treatment at a tertiary hospital in southern Brazil. All subjects provided written informed consent, answered demographic/behavioral questionnaires through audio computer-assisted self-interviews (ACASI), and collected blood and vaginal samples for biological markers and assessment of sexually transmitted infections (STIs). HIV-negative partners were counseled and tested for HIV-1. Results: The study population mean age was 39.9 years, 53.6% were female, 62.5% were Caucasian, 52.6% had incomplete or complete elementary education, 63.1% resided in Porto Alegre. Demographic, behavioral and biological marker characteristics were similar between couples and single individuals. There was an association between adherence reported on ACASI and an undetectable serum viral load (P<0.0001). Logistic regression analysis demonstrated that single-tablet ARV-regimens were independently associated with adherence (OR = 2.3; 95CI%: 1.2–4.4; P = 0.011) after controlling for age, gender, education, marital status, personal income, ARV regimen, and median time of ARV use. A positive correlation between genital secretion PCR results and serum viral load was significant in the presence of STIs (r = 0.359; P = 0.017). Although HIV PCR detection in vaginal secretions was more frequent in women with detectable viremia (9/51, 17.6%), it was also present in 7 of 157 women with undetectable serum viral loads (4.5%), p = 0.005. Conclusions: ARV single tablet regimens are associated with adherence. Detectable HIV-1 may be present in the genital secretions of women with undetectable viremia which means there is potential for HIV transmission in adherent individuals with serologic suppression.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPloS one. San Francisco. Vol. 14, no. 2 (Feb. 2019), e0212744, 14 p.pt_BR
dc.rightsOpen Accessen
dc.subjectViral loaden
dc.subjectCarga viralpt_BR
dc.subjectHIV-1pt_BR
dc.subjectHIV-1en
dc.subjectSecretionen
dc.subjectInfecções sexualmente transmissíveispt_BR
dc.subjectHIVen
dc.subjectBiomarcadorespt_BR
dc.subjectViremiapt_BR
dc.subjectHIV preventionen
dc.subjectSexually transmitted diseasesen
dc.subjectBiomarkersen
dc.subjectViremiaen
dc.titleAntiretroviral adherence and virologic suppression in partnered and unpartnered HIV-positive individuals in southern Brazilpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001111646pt_BR
dc.type.originEstrangeiropt_BR


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