Diagnostic value of presepsin in sepsis

Abstract

Sepsis is a Systemic Inflammatory Response Syndrome (SIRS) caused by proven or presumed infection. Some studies show that early recognition, influence the outcome of patients decreasing mortality. Culture exams are the gold standard to diagnose sepsis, but have the time as inconvenience. The presepsin protein has been studied as a marker of sepsis diagnoses, and the results are available around 2 hours after collection of blood. This study aims to establish the diagnostic value of presepsin levels in sepsis. Prospective observational study Were included 109 patients with more than 18 years with criteria for sirs on arrival at the emergency services. The values of presepsin were measured in blood samples up to 06 hours of hospitalization and after 48 hours of hospitalization. Secondary data were obtained through medical records. Were excluded from the study patients less than 18 years of age Patients were separated into two groups, one of SIRS and the other with confirmed or probable sepsis(strong clinical suspicion).The mean values of presepsin in patients with confirmed / probable sepsis were 2,926(DP 1194) and 1749 (701) in the SIRS patients. The Student’s T test was used for unpaired samples, and it was observed that, among the values of these 2 groups, there was difference with statistical significance (p<0,01).The accuracy of presepsin values for the detection of sepsis, through the ROC curve, presented Area Under The Curve (AUC) de 0,787(IC 95%- 0,686-0,889), p < 0,01. Presepsin proved to be a biomarker with good sensitivity and specificity in the diagnosis of sepsis.