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dc.contributor.authorGus, Patricia Ioschpept_BR
dc.contributor.authorMarinho, Diane Ruschelpt_BR
dc.contributor.authorZelanis, Samira K.pt_BR
dc.contributor.authorBelló-Klein, Adrianept_BR
dc.contributor.authorLocatelli, Claudete Inêspt_BR
dc.contributor.authorNicola, Felipe Fernandespt_BR
dc.contributor.authorKunzler, Ana Laura Fischerpt_BR
dc.contributor.authorPiedras, Tania Regina Gattelli Fernandespt_BR
dc.contributor.authorCarraro, Cristina Campospt_BR
dc.contributor.authorSousa, Luciene Barbosa dept_BR
dc.date.accessioned2020-02-08T04:20:34Zpt_BR
dc.date.issued2016pt_BR
dc.identifier.issn1942-0994pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/205606pt_BR
dc.description.abstractImportance. Autologous serum (AS) eye drops are recommended for severe dry eye in patients with ocular surface disease. No description of the antioxidant balance of AS eye drops has been reported in the literature. Objective. This study sought to evaluate the total reactive antioxidant potential (TRAP) and concentration of reactive oxygen species (ROS) in samples of 50% AS eye drops and their correlations with the demographic characteristics and lifestyle habits of patients with ocular surface disease and healthy controls. Design. This was a case-control study with a 3-month follow-up period. Participants. 16 patients with severe dry eye disease of different etiologies and 17 healthy controls matched by age, gender, and race were included. Results. TRAP and ROS were detected at all evaluated times. There were no differences in the mean ROS () or TRAP () levels between cases and controls. No statistically significant differences in the concentrations of ROS or TRAPs were found at 0, 15, or 30 days ( for ROS = 0.087 and for TRAP = 0.93). Neither the demographic characteristics nor the lifestyle habits were correlated with the oxidative balance of the 50% AS eye drops. Conclusions and Relevance. Both fresh and frozen 50% AS eye drops present antioxidant capacities and ROS in an apparently stable balance. Moreover, patients with ocular surface disease and normal controls produce equivalent AS eye drops in terms of oxidative properties.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofOxidative medicine and cellular longevity. New York. v. 2016 (2016), ID 9780193, 5 p.pt_BR
dc.rightsOpen Accessen
dc.subjectEspécies de oxigênio reativaspt_BR
dc.subjectEstudos de casos e controlespt_BR
dc.subjectSíndromes do olho secopt_BR
dc.titleA Case-Control Study on the Oxidative Balance of 50% Autologous Serum Eye Dropspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001003639pt_BR
dc.type.originEstrangeiropt_BR


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