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dc.contributor.authorSato, João Ricardopt_BR
dc.contributor.authorHoexter, Marcelo Queirozpt_BR
dc.contributor.authorCastellanos, Xavier Franciscopt_BR
dc.contributor.authorRohde, Luis Augusto Paimpt_BR
dc.date.accessioned2019-10-24T03:48:54Zpt_BR
dc.date.issued2012pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/200964pt_BR
dc.description.abstractStudies based on functional magnetic resonance imaging (fMRI) during the resting state have shown decreased functional connectivity between the dorsal anterior cingulate cortex (dACC) and regions of the Default Mode Network (DMN) in adult patients with Attention-Deficit/Hyperactivity Disorder (ADHD) relative to subjects with typical development (TD). Most studies used Pearson correlation coefficients among the BOLD signals from different brain regions to quantify functional connectivity. Since the Pearson correlation analysis only provides a limited description of functional connectivity, we investigated functional connectivity between the dACC and the posterior cingulate cortex (PCC) in three groups (adult patients with ADHD, n = 21; TD age-matched subjects, n = 21; young TD subjects, n = 21) using a more comprehensive analytical approach – unsupervised machine learning using a one-class support vector machine (OC-SVM) that quantifies an abnormality index for each individual. The median abnormality index for patients with ADHD was greater than for TD agematched subjects (p = 0.014); the ADHD and young TD indices did not differ significantly (p = 0.480); the median abnormality index of young TD was greater than that of TD age-matched subjects (p = 0.016). Low frequencies below 0.05 Hz and around 0.20 Hz were the most relevant for discriminating between ADHD patients and TD age-matched controls and between the older and younger TD subjects. In addition, we validated our approach using the fMRI data of children publicly released by the ADHD-200 Competition, obtaining similar results. Our findings suggest that the abnormal coherence patterns observed in patients with ADHD in this study resemble the patterns observed in young typically developing subjects, which reinforces the hypothesis that ADHD is associated with brain maturation deficits.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPLoS ONE. San Francisco. Vol. 7, no. 9 (Sep. 2012), e45671, 9 p.pt_BR
dc.rightsOpen Accessen
dc.subjectEncéfalopt_BR
dc.subjectAdultopt_BR
dc.subjectTranstorno do déficit de atenção com hiperatividadept_BR
dc.titleAbnormal brain connectivity patterns in adults with ADHD : a coherence studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000866726pt_BR
dc.type.originEstrangeiropt_BR


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