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dc.contributor.authorAlves, Andressa de Freitaspt_BR
dc.contributor.authorBaldissera, Vanessa Didopt_BR
dc.contributor.authorChiela, Eduardo Cremonese Filippipt_BR
dc.contributor.authorCerski, Carlos Thadeu Schmidtpt_BR
dc.contributor.authorFontes, Paulo Roberto Ottpt_BR
dc.contributor.authorFernandes, Marilda da Cruzpt_BR
dc.contributor.authorPorawski, Marilenept_BR
dc.contributor.authorGiovenardi, Márciapt_BR
dc.date.accessioned2019-10-17T03:51:58Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn1130-0108pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/200771pt_BR
dc.description.abstractBackground and aim: hepatocellular carcinoma is a type of cancer related with inflammation, as 90% of cases develop in a chronic inflammation condition. Excess inflammation can affect tissue homeostasis. Cytokines and inflammatory mediators are immunological components that can influence the functioning of cells and tissues. In addition, the estrogen receptor appears to play an important role in hepatocarcinogenesis. The aim of the study was to evaluate the expression of inflammatory markers and ER in patients with hepatocellular carcinoma. Methods: data from 143 patients of ISCMPA were analyzed. Immunohistochemistry was performed of cyclooxygenase-2 enzyme (COX-2), nuclear factor kappa B (NF-κB), tumor necrosis factor alpha (TNF-α) and ER in paraffin-embedded hepatic tissue. The percentage of the stained area, intensity of staining and of the number of ER positive nuclei were evaluated using the ImageJ 1.50 software. Results and conclusion: there was a significant difference between the groups in terms of the percentage of marked area (p = 0.040) for COX-2 and the intensity of staining of TNF-α (p = 0.030). No significant differences were observed in any of other parameters evaluated. In conclusion, COX2 and TNF-α are possible markers that should be further studied to determine their immunohistochemical profile and role in HCC development.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofRevista española de enfermedades digestivas. Madrid. Vol. 111, no. 5 (2019), p. 364-370pt_BR
dc.rightsOpen Accessen
dc.subjectCarcinoma hepatocelularpt_BR
dc.subjectHepatocelular carcinomaen
dc.subjectImuno-histoquímicapt_BR
dc.subjectImmunohistochemistryen
dc.subjectInflammationen
dc.subjectInflamaçãopt_BR
dc.subjectCiclooxigenase-2en
dc.subjectFator de necrose tumoral alfapt_BR
dc.subjectNF-kappa Bpt_BR
dc.subjectTumor necrosis factor-alphaen
dc.subjectExpressão gênicapt_BR
dc.subjectNuclear kappa B factoren
dc.subjectBiomarcadorespt_BR
dc.titleAltered expression of COX-2 and TNF-α in patients with hepatocellular carcinomapt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001104475pt_BR
dc.type.originEstrangeiropt_BR


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