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dc.contributor.authorRodrigues, Luciana Tovopt_BR
dc.contributor.authorSchneider, Bruna Celestinopt_BR
dc.contributor.authorSilva, Thais Martins dapt_BR
dc.contributor.authorSilva, Bianca Del Ponte dapt_BR
dc.contributor.authorLoret De Mola, Christianpt_BR
dc.contributor.authorFaccini, Lavinia Schulerpt_BR
dc.contributor.authorVianna, Fernanda Sales Luizpt_BR
dc.contributor.authorMunhoz, Tiago Neuenfeldpt_BR
dc.contributor.authorEntiauspe, Ludmila Gonçalvespt_BR
dc.contributor.authorSilveira, Mariângela Freitas dapt_BR
dc.contributor.authorSantos, Iná da Silva dospt_BR
dc.contributor.authorMatijasevich, Aliciapt_BR
dc.contributor.authorBarros, Aluisio Jardim Dornellas dept_BR
dc.contributor.authorRohde, Luis Augusto Paimpt_BR
dc.contributor.authorBertoldi, Andréa Dâmasopt_BR
dc.date.accessioned2019-10-11T03:55:58Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn1471-244Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/200537pt_BR
dc.description.abstractBackground: Longitudinal studies have consistently reported that prenatal exposure to acetaminophen can to lead to an increased risk of attention deficit-hyperactivity disorder during childhood. This study aimed to investigate the association between intrauterine exposure to acetaminophen and the presence of emotional and behavioral problems at the ages of 6 and 11 years in a low-middle income country. Methods: We performed a prospective longitudinal population-based study using data from the 2004 Pelotas birth cohort. From the 4231 initial cohort participants, 3722 and 3566 children were assessed at 6 and 11 years of age, respectively. The outcomes were assessed using the parent version of Strengths and Difficulties Questionnaire (SDQ). The cut-off points established for the Brazilian population were used to categorize the outcomes. Crude and adjusted odds ratio were obtained through logistic regression. Results: Acetaminophen was used by 27.5% (95% confidence interval [CI]: 26.1–28.9) of the mothers at least once during pregnancy. The prevalence of emotional problems at 6 and 11 years was 13.6 and 19.9%, respectively. For hyperactivity problems, prevalence was 13.9 and 16.1%, respectively. Intrauterine exposure to acetaminophen increased the odds of having emotional (odds ratio [OR] = 1.47; 95% CI: 1.07–2.02) and hyperactivity/inattention (OR = 1.42; 95% CI: 1.06–1.92) problems in 6-year-old boys. At the age of 11, a small decrease in the effect was observed for both outcomes after adjustment: OR = 1.31 (95% CI: 0.99–1.73) for emotional problems and OR = 1.25 (95% CI: 0.95–1.65) for hyperactivity/inattention in boys. No association for any phenotypes at both ages was observed for girls. Conclusion: The effect of intrauterine exposure to acetaminophen in emotional and hyperactivity symptoms was dependent on sex in a Brazilian cohort. While it seemed to be important for boys, mainly at 6 years of age, for girls, no association was observed.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBMC psychiatry. London. Vol. 18 (2018), 368, 11 p.pt_BR
dc.rightsOpen Accessen
dc.subjectAcetaminofenpt_BR
dc.subjectAcetaminophen (paracetamol)en
dc.subjectPrenatal exposureen
dc.subjectEfeitos tardios da exposição pré-natalpt_BR
dc.subjectGravidezpt_BR
dc.subjectBirth cohorten
dc.subjectBehavioral symptomsen
dc.subjectSintomas comportamentaispt_BR
dc.subjectEstudos longitudinaispt_BR
dc.subjectPelotas (RS)pt_BR
dc.titleIs intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? : findings from the 2004 Pelotas birth cohortpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001100315pt_BR
dc.type.originEstrangeiropt_BR


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