Effect of polymyxin B-containing regimens on renal function for the treatment of carbapenem-resistant Enterobacteriacea mediastinitis

Abstract

A retrospective cohort study, were evaluated: polymyxin B plus aminoglycosides orpolymyxin B plus other antibiotics. Any degree of acute kidney injury occurred in 26 (86.6%)patients. The median time to acute kidney injury was 6.0 (95% CI 3–14) days in the polymyxin-aminoglycoside containing regimen group, against 27.0 (95% CI 6–42) days in the polymyxinwith other antimicrobial combinations group (p = 0.03). Polymyxin B with aminoglycosidesgroup progressed faster to any degree of renal dysfunction.