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dc.contributor.authorDick, Sofia Michelept_BR
dc.contributor.authorQueiroz, Marina dept_BR
dc.contributor.authorBrondani, Letícia de Almeidapt_BR
dc.contributor.authorDall'Agnol, Angélicapt_BR
dc.contributor.authorBernardi, Bárbara Luizapt_BR
dc.contributor.authorSilveiro, Sandra Pinhopt_BR
dc.date.accessioned2019-10-10T03:49:20Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn1434-6621pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/200329pt_BR
dc.description.abstractPrimary aldosteronism (PA) is a group of disorders in which aldosterone is excessively produced. These disorders can lead to hypertension, hypokalemia, hypervolemia and metabolic alkalosis. The prevalence of PA ranges from 5% to 12% around the globe, and the most common causes are adrenal adenoma and adrenal hyperplasia. The importance of PA recognition arises from the fact that it can have a remarkably adverse cardiovascular and renal impact, which can even result in death. The aldosterone-to-renin ratio (ARR) is the election test for screening PA, and one of the confirmatory tests, such as oral sodium loading (OSL) or saline infusion test (SIT), is in general necessary to confirm the diagnosis. The distinction between adrenal hyperplasia (AH) or aldosterone-producing adenoma (APA) is essential to select the appropriate treatment. Therefore, in order to identify the subtype of PA, imaging exams such as computed tomography or magnetic ressonance imaging, and/or invasive investigation such as adrenal catheterization must be performed. According to the subtype of PA, optimal treatment – surgical for APA or pharmacological for AH, with drugs like spironolactone and amiloride – must be offered.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofClinical chemistry and laboratory medicine. Berlin. Vol. 56, no. 3 (2018), p. 360-372pt_BR
dc.rightsOpen Accessen
dc.subjectHiperaldosteronismopt_BR
dc.subjectAdrenal vein samplingen
dc.subjectArterial hypertensionen
dc.subjectDiagnósticopt_BR
dc.subjectHypokalemiaen
dc.subjectHipertensãopt_BR
dc.subjectHipopotassemiapt_BR
dc.subjectOral sodium loadingen
dc.subjectRevisãopt_BR
dc.subjectPrimary aldosteronismen
dc.titleUpdate in diagnosis and management of primary aldosteronismpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001102422pt_BR
dc.type.originEstrangeiropt_BR


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