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dc.contributor.authorPolina, Evelise Reginapt_BR
dc.contributor.authorAraújo, Raquel Rosa Candebat Vallejopt_BR
dc.contributor.authorSbruzzi, Renan Cesarpt_BR
dc.contributor.authorBiolo, Andreiapt_BR
dc.contributor.authorRohde, Luis Eduardo Paimpt_BR
dc.contributor.authorClausell, Nadine Oliveirapt_BR
dc.contributor.authorSantos, Kátia Gonçalves dospt_BR
dc.date.accessioned2019-09-26T03:45:18Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/199785pt_BR
dc.description.abstractDysregulated expression of tissue inhibitors of matrix metalloproteinases (TIMPs) is associated with systolic dysfunction and worsening heart failure (HF). However, no study has assessed the relationship between TIMP polymorphisms and chronic HF. In this study, 300 HF outpatients with reduced left ventricular ejection fraction and 304 healthy blood donors were genotyped for the 372 T > C polymorphism (Phe124Phe; rs4898) in the TIMP-1 gene and the −418 G > C polymorphism (rs8179090) in the TIMP-2 gene to investigate whether these polymorphisms are associated with HF susceptibility and prognosis. The genotype and allele frequencies of the 372 T > C polymorphism in HF patients were not significantly different from those observed among healthy subjects, and the C allele of the −418 G > C polymorphism was very rare in our population (frequency < 1%). After a median follow-up duration of 5.5 years, 121 patients (40.3%) died (67 of them from HF). Survival analysis did not show statistically significant differences in all-cause death and HF-related death between patients with and without the T allele (P > 0.05 for all comparisons). Thus, our findings do not support the hypothesis that the 372 T > C (Phe124Phe) polymorphism in the TIMP-1 gene and the −418 G > C polymorphism in the TIMP-2 gene are associated with HF susceptibility and prognosis in Southern Brazilians.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofScientific reports. London. Vol. 8 (2018), 9446, 8 p.pt_BR
dc.rightsOpen Accessen
dc.subjectPolimorfismo genéticopt_BR
dc.subjectInibidor tecidual de metaloproteinase-2pt_BR
dc.subjectInibidor tecidual de metaloproteinase-1pt_BR
dc.subjectDoença crônicapt_BR
dc.subjectBrasil, Região Sulpt_BR
dc.subjectInsuficiência cardíacapt_BR
dc.titleRelationship of polymorphisms in the tissue inhibitor of metalloproteinase (TIMP)-1 and -2 genes with chronic heart failurept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001101105pt_BR
dc.type.originEstrangeiropt_BR


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