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dc.contributor.authorPeres, Letícia Pangendlerpt_BR
dc.contributor.authorCartell, Andre da Silvapt_BR
dc.contributor.authorCestari, Tania Ferreirapt_BR
dc.contributor.authorOliveira, Fabiana Bazanella dept_BR
dc.contributor.authorMazzotti, Nicolle Gollopt_BR
dc.date.accessioned2019-09-18T03:44:26Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn0365-0596pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/199387pt_BR
dc.description.abstractBackground: Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-tocontrol symptom. The mediators involved in psoriatic pruritus have not been fully established. Objective: To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus. Methods: 29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed. A questionnaire was administered to obtain clinical information and the Dermatology Life Quality Index. Pruritus was assessed using a visual analog scale and skin biopsies were performed for staining with Giemsa and Immunohistochemistry with C-Kit. Results: Pruritus was observed in 91.3% of our patients. Median VAS was 6 (p25-75: 2-8). The immunohistochemical method revealed a mean of 11.32 mast cells/field and Giemsa staining revealed a mean of 6.72 mast cells/field. There was no correlation between the intensity of pruritus and mast cell count, neither in Immunohistochemistry (p = 0.15; rho = -0.27) nor in Giemsa (p = 0.16; rho = -0.27). Pruritus did not impact on the Dermatology Life Quality Index (p = 0.51; rho = -0.13). Study limitations: The small sample size may be considered the main limitation of our study. Conclusions: Although mast cells are mediators of pruritus in many cutaneous diseases, our findings support that psoriatic pruritus is a complex disorder with multifactorial, complex pathophysiology, involving pruritogenic mediators others than mast cells.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofAnais brasileiros de dermatologia. Vol. 93, no. 3 (2018), p. 368-372pt_BR
dc.rightsOpen Accessen
dc.subjectMast cellsen
dc.subjectPsoríasept_BR
dc.subjectPruritusen
dc.subjectPruridopt_BR
dc.subjectMastócitospt_BR
dc.subjectPsoriasisen
dc.subjectEstudos transversaispt_BR
dc.titleDensity of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001101647pt_BR
dc.type.originNacionalpt_BR


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