Mostrar registro simples

dc.contributor.authorWerlang, Isabel Cristina Ribaspt_BR
dc.contributor.authorMueller, Noel Theodorept_BR
dc.contributor.authorPizoni, Alinept_BR
dc.contributor.authorWisintainer, Henrique Porto da Rochapt_BR
dc.contributor.authorMatte, Ursula da Silveirapt_BR
dc.contributor.authorCosta, Sergio Hofmeister de Almeida Martinspt_BR
dc.contributor.authorRamos, José Geraldo Lopespt_BR
dc.contributor.authorGoldani, Marcelo Zubaranpt_BR
dc.contributor.authorDominguez-Bello, Maria G.pt_BR
dc.contributor.authorGoldani, Helena Ayako Suenopt_BR
dc.date.accessioned2019-07-13T02:36:08Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/196919pt_BR
dc.description.abstractThe associations of Cesarean delivery with offspring metabolic and immune-mediated diseases are believed to derive from lack of mother-to-newborn transmission of specific microbes at birth. Bifidobacterium spp., in particular, has been hypothesized to play a health-promoting role, yet little is known about how delivery mode modifies colonization of the newborn by this group of microbes. The aim of this research was to examine the presence of Bifidobacterium in meconium and in the transitional stool, and to assess cytokine levels and hematological parameters in the venous cord blood of infants born by elective, pre-labor Cesarean section vs. vaginal delivery in Southern Brazil. We recruited 89 mothernewborn pairs (23 vaginal delivery and 66 elective cesarean delivery), obtained demographic information from a structured questionnaire and clinical information from medical records. We obtained umbilical cord venous blood and meconium samples following delivery and the transitional stool (the first defecation after meconium) before discharge. We determined plasma levels of IL-1β, IL-10, IL-6, GM-CSF, IL-5, IFN-γ, TNF-α, IL-2, IL-4 and IL-8 in the cord blood, and presence of stool Bifidobacterium by real time PCR. Compared to vaginally-delivered neonates, Cesarean-delivered neonates had a lower leukocyte count (p = 0.037), lower hemoglobin (p = 0.04), and lower levels of the cytokine GM-CSF (p = 0.009) in the cord blood. Moreover, Bifidobacterium was detected less often in the transitional stool of Cesarean-delivered neonates compared to vaginally-delivered neonates (p = 0.001). The results indicate that pre-labor Cesarean birth may be associated with microbial and hematological alterations in the neonate. The clinical significance of these findings remains to be determined in larger prospective birth cohort studies.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPlos One. San Francisco. Vol. 13, no. 11 (Nov. 2018), e0205962, 10 p.pt_BR
dc.rightsOpen Accessen
dc.subjectCesáreapt_BR
dc.subjectInfecções por Bifidobacterialespt_BR
dc.subjectCitocinaspt_BR
dc.subjectLeucócitospt_BR
dc.subjectSangue fetalpt_BR
dc.subjectRecém-nascidopt_BR
dc.titleAssociations of birth mode with cord blood cytokines, white blood cells, and newborn intestinal bifidobacteriapt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001095589pt_BR
dc.type.originEstrangeiropt_BR


Thumbnail
   

Este item está licenciado na Creative Commons License

Mostrar registro simples