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Citoquinas e troponina-I em disfunção cardíaca após cirurgia de revascularização miocárdia com circulação extracorpórea
dc.contributor.author | Savaris, Neverton | pt_BR |
dc.contributor.author | Polanczyk, Carisi Anne | pt_BR |
dc.contributor.author | Clausell, Nadine Oliveira | pt_BR |
dc.date.accessioned | 2010-04-16T09:11:10Z | pt_BR |
dc.date.issued | 2001 | pt_BR |
dc.identifier.issn | 0066-782X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/19676 | pt_BR |
dc.description.abstract | Objective - The association between cytokines and troponin-I with cardiac function after cardiac surgery with cardiopulmonary bypass remains a topic of continued investigation. Methods - Serial measurements, within 24h following surgery, of tumor necrosis factor-α, its soluble receptors, and troponin-I were performed in patients with normal ejection fraction undergoing coronary artery bypass grafting. Ejection fraction was measured by radioisotopic ventriculography preoperatively, at 24h and at day 7 postoperatively. Results - Of 19 patients studied (59±8.5 years), 10 (group 1) showed no changes in ejection fraction, 53±8% to 55±7%, and 9 (group 2) had a decrease in ejection fraction, 60±11% to 47±11% (p=0.015) before and 24h after coronary artery bypass grafting, respectively. All immunological variables, except tumor necrosis factor-α soluble receptor I at 3h postoperation (5.5± 0.5 in group 1 versus 5.9±0.2 pg/ml in group 2; p=0.048), were similar between groups. Postoperative troponin-I had an inverse correlation with ejection fraction at 24h (r= -0.44). Conclusions - Inflammatory activity, assessed based on tumor necrosis factor-α and its receptors, appears to play a minor role in cardiac dysfunction after cardiac surgery. Troponin I levels are inversely associated with early postoperative ejection fraction. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | por | pt_BR |
dc.relation.ispartof | Arquivos brasileiros de cardiologia. São Paulo. vol. 77, n. 2 (ago. 2001), p. 107-113 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Cytokines | en |
dc.subject | Cirurgia torácica | pt_BR |
dc.subject | Troponin-I | en |
dc.subject | Myocardial function | en |
dc.subject | Inflammatory response | en |
dc.title | Citoquinas e troponina-I em disfunção cardíaca após cirurgia de revascularização miocárdia com circulação extracorpórea | pt_BR |
dc.title.alternative | Cytokines and troponin-I in cardiac dysfunction after coronary artery grafting with cardiopulmonary bypass | en |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000377592 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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