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dc.contributor.authorD'Avila, Ângela Marconpt_BR
dc.contributor.authorBiolchi, Vanderleipt_BR
dc.contributor.authorKliemann, Lucia Mariapt_BR
dc.contributor.authorCapp, Edisonpt_BR
dc.contributor.authorCorleta, Helena von Eyept_BR
dc.date.accessioned2019-07-10T02:34:44Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn1757-2215pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/196751pt_BR
dc.description.abstractBackground: A cohort study was performed to identify ovarian reserve markers (ORM) that predicts amenorrhea or oligomenorrhea 6 months after cyclophosphamide CTX in women with breast cancer. Methods: 52 eumenorrheic patients with breast cancer were enrolled. FSH, anti-Müllerian hormone (AMH), antral follicles count (AFC) were measured before and 6 months after CTX. A logistic regression for independent samples and determination of the ROC curve were performed. Results: The age of 32 years presented 96 % of sensitivity and 39 % of specificity to predict amenorrhea or oligomenorrhea with ROC area under the curve (AUC) of 0.77. ovarian reserve marker (ORM) with power to predict amenorrhea or oligomenorrhea in women after CTX were AMH <3.32 ng/mL (sensitivity of 85 %, specificity of 75 % and AUC 0.87), AFC <13 follicles (sensitivity 81 %, specificity 62 %, AUC 0.81). AMH cutoff to predict amenorrhea was 1.87 ng/mL (sensitivity 82 %, specificity 83 %, AUC 0.84) and AFC cutoff was 9 follicles (sensitivity 71 %, specificity 78 %, AUC 0.73). Conclusions: ≥32-years-old women, AMH <3.32 ng/mL and AFC <13 follicles determined significantly higher risk of amenorrhea or oligomenorrhea after CTX with cyclophosphamide. The ORM age (≥32 years) analyzed together with AMH or AFC increases sensitivity and specificity in predicting amenorrhea or oligomenorrhea.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofJournal of ovarian research. London. Vol. 8, no. 82 (2015), 6 p.pt_BR
dc.rightsOpen Accessen
dc.subjectAnovulaçãopt_BR
dc.subjectAnti-Müllerian hormoneen
dc.subjectAntral follicles counten
dc.subjectHormônio antimüllerianopt_BR
dc.subjectOvarian reserveen
dc.subjectReserva ovarianapt_BR
dc.subjectAmenorrhea related chemotherapyen
dc.subjectAnovulation related chemotherapyen
dc.titleAge, anti-müllerian hormone, antral follicles count to predict amenorrhea or oligomenorrhea after chemotherapy with cyclophosphamidept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000989420pt_BR
dc.type.originEstrangeiropt_BR


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