Compartmental analysis of ranitidine doubled peak plasma profile after oral administration to health volunteers
dc.contributor.author | Schuck, Virna Josiane Aurelio | pt_BR |
dc.contributor.author | Barros, Sergio Gabriel Silva de | pt_BR |
dc.contributor.author | Schapoval, Elfrides Eva Scherman | pt_BR |
dc.contributor.author | Gruber, Antonio Carlos | pt_BR |
dc.contributor.author | Dalla Costa, Teresa Cristina Tavares | pt_BR |
dc.date.accessioned | 2010-04-16T09:10:39Z | pt_BR |
dc.date.issued | 2002 | pt_BR |
dc.identifier.issn | 1516-9332 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/19556 | pt_BR |
dc.description.abstract | The aim of this study was to describe the double peak plasma pharmacokinetic profile of ranitidine after oral administration to healthy volunteers using non-compartmental and compartmental analysis. A single 300 mg dose of ranitidine was given to ten healthy volunteers (5 male and 5 female). Blood samples were drawn at different times and analyzed by HPLC. Plasma profiles were evaluated by non-compartmental and compartmental approaches. The non-compartmental parameters determined were k (0.0054 ± 0.0010 min-1), t1/2 (2.2 ± 0.4 h), Vdss/F (265.3 ± 70.6 L), Cl/F (84.8 ± 24.3 L/h) and AUC (225916 ± 54099 ng*min/mL). The compartmental analysis was carried out using a two compartments body model, with first order absorption from two different sites. The parameters determined were k21 (0.0149 ± 0.0133 min-1), ka1 (0.0117 ± 0.0073 min-1), ka2 (0.1496 ± 0.1699 min-1), Vc (128 ± 75.2 L), a (0.0299 ± 0.0319 min-1), b (0.0074 ± 0.0014 min-1) and time for the beginning of the absorption from the second site (126.7 ± 58.1 min). The model used in the compartmental analysis was adequate to describe the double peak of ranitidine plasma profile and to determine the pharmacokinetic parameters. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Revista brasileira de ciências farmacêuticas. São Paulo, SP. Vol. 38, n. 2 (abr./jun. 2002), p. 183-190 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Ranitidina | pt_BR |
dc.subject | Ranitidine | en |
dc.subject | Pharmacokinetics | en |
dc.subject | Administração oral | pt_BR |
dc.subject | Compartmental analysis | en |
dc.subject | Ensaio clínico controlado | pt_BR |
dc.subject | Farmacocinética | pt_BR |
dc.subject | Double peak plasma profile | en |
dc.title | Compartmental analysis of ranitidine doubled peak plasma profile after oral administration to health volunteers | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000336526 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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