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    • Phaeohyphomycosis : a clinical-epidemiological and diagnostic study of eighteen cases in Rio Grande do Sul, Brazil 

      Severo, Cecília Bittencourt; Oliveira, Flávio de Mattos; Pilar, Emily Ferreira Salles; Severo, Luiz Carlos (2012) [Artículo de periódico]
      The goal of this study was to review 18 cases of phaeohyphomycosis in Rio Grande do Sul. The records of all of the patients with a diagnosis of phaeohyphomycosis between 1995-2010 were reviewed. Twelve of the 18 patients ...

    • Pharmacogenomics and cardiovascular disease : where are we and where do we go from here? 

      Stein, Ricardo; Beuren, Thaís Mariel Andara; Cela, Luis Ramudo; Lacerda, Filipe Ferrari Ribeiro de (2020) [Artículo de periódico]
      Pharmacogenomics (PGx) studies the interaction between genes and drugs. By analysis of specific regions of DNA, it is possible to obtain information on patient’s metabolization profile of a given drug, as well as the ...

    • Pharmacokinetics comparison of two pegylated interferon alfa formulations in healthy volunteers 

      Costa, Marisa Boff da; Picon, Paulo Dornelles; Sander, Guilherme Becker; Nodarse Cuni, Hugo; Valenzuela Silva, Carmen M; Páez Meireles, Rolando; Góes, Ana Carolina Magalhães Andrade; Batoreu, Nadia Maria; Maia, Maria de Lourdes de Sousa; Albuquerque, Elizabeth Maciel; Matos, Denise Cristina de Souza; López Saura, Pedro Antonio (2018) [Artículo de periódico]
      Background: Several countries have used pegylation technology to improve the pharmacokinetic properties of essential drugs. Recently, a novel interferon alfa-2b protein conjugated to four-branched 12 kDa polyethylene glycol ...

    • Pharmacological adherence to oral anticoagulant and factors that influence the International Normalized Ratio Stability 

      Ávila, Christiane Wahast; Aliti, Graziella Badin; Feijó, Maria Karolina Echer Ferreira; Silva, Eneida Rejane Rabelo da (2011) [Artículo de periódico]
      Este é um estudo transversal, desenvolvido com o objetivo de relacionar a estabilidade do índice de normatização internacional (INR), utilizado como parâmetro para monitorar os níveis de coagulação do sangue, com adesão, ...

    • Pharmacological properties of specioside from the stem bark of Tabebuia aurea 

      Nocchi, Samara Requena; Kato, Natália Naomi; Almeida, Júlio Menta de; Ferreira, Alda Maria Teixeira; Kadri, Mônica Cristina Toffoli; Meirelles, Lyvia Eloiza de Freitas; Damke, Gabrielle Marconi Zago Ferreira; Consolaro, Márcia Edilaine Lopes; Rigo, Graziela de Vargas; Macedo, Alexandre José; Tasca, Tiana; Reis, Sharon Vieira dos; Alves, Flávio Macedo; Carollo, Carlos Alexandre; Silva, Denise Brentan (2020) [Artículo de periódico]
      Iridoids are secondary metabolites with several biological activities. They are often found in species of the genus Tabebuia Gomes ex A.P. de Candolle. Tabebuia aurea (Silva Manso) Benth. & Hook. F. ex S. Moore, Bignoniaceae, ...

    • Pharmacological treatment and staging in bipolar disorder : evidence from clinical practice 

      Goi, Pedro Domingues; Bücker, Joana; Sulzbach, Miréia Fortes Vianna; Rosa, Adriane Ribeiro; Grande, Iria; Chendo, Inês; Sodré, Leonardo de Almeida; Kauer-Sant'Anna, Márcia; Silveira, Leonardo Evangelista da; Kunz, Maurício; Ceresér, Keila Maria Mendes; Gama, Clarissa Severino; Massuda, Raffael (2015) [Artículo de periódico]
      Objective: Staging models for medical diseases are widely used to guide treatment and prognosis. Bipolar disorder (BD) is a chronic condition and it is among the most disabling disorders in medicine. The staging model ...

    • Pharmacotherapy of bipolar disorder in children and adolescents : an update 

      Peruzzolo, Tatiana Lauxen; Tramontina, Silzá; Rohde, Luis Augusto Paim; Zeni, Cristian Patrick (2013) [Artículo de periódico]
      Objective: To review the options for acute and maintenance pharmacological treatment of bipolar disorder in children and adolescents, including the treatment of bipolar depression and comorbid attention deficit/hyperactivity ...

    • A phase 2, double-blind, placebo-controlled, randomized study of fresolimumab in patients with steroid-resistant primary focal segmental glomerulosclerosis 

      Vincenti, Flavio; Fervenza, Fernando Custodio; Campbell, Kirk Nicholas; Díaz, Montserrat M.; Gesualdo, Loreto; Nelson, Peter; Praga, Manuel; Radhakrishnan, Jai; Sellin, Lorenz K.; Singh, Ajay; Thornley-Brown, Denyse P.; Veronese, Francisco José Veríssimo; Accomando, Beverly; Engstrand, Sara; Ledbetter, Steven R.; Lin, Julie; Neylan, John F.; Tumlin, James A.; Focal Segmental Glomerulosclerosis Study Group (2017) [Artículo de periódico]
      Introduction: Steroid-resistant focal segmental glomerulosclerosis (SR-FSGS) is a common glomerulopathy associated with nephrotic range proteinuria. Treatment goals are reduction in proteinuria, which can delay end-stage ...

    • A phase II, randomized, double-blind, placebo controlled, dose-response trial of the melatonin effect on the pain threshold of healthy subjects 

      Stefani, Luciana Paula Cadore; Müller, Suzana; Torres, Iraci Lucena da Silva; Razzolini, Bruna Regis; Rozisky, Joanna Ripoll; Fregni, Felipe; Markus, Regina Pekelmann; Caumo, Wolnei (2013) [Artículo de periódico]
      Background: Previous studies have suggested that melatonin may produce antinociception through peripheral and central mechanisms. Based on the preliminary encouraging results of studies of the effects of melatonin on pain ...

    • pH effect on stability and kinetics degradation of nitazoxanide in solution 

      Barbosa, Fábio de Souza; Pezzi, Leonardo Capra; Sorrentino, Julia Medeiros; Steppe, Martin; Volpato, Nadia Maria; Mendez, Andreas Sebastian Loureiro (2020) [Artículo de periódico]
      Stability studies correspond to a set of tests designed to assess changes in the quality of a given drug over time and under the influence of a number of factors. Among these factors, pH plays an important role, due to the ...

    • Phenolic enriched extract of baccharis trimera presents anti-inflammatory and antioxidant activities 

      Oliveira, Cristiane Bernardes de; Comunello, Lucimara Nardi; Lunardelli, Adroaldo; Amaral, Robson Henrich; Pires, Melissa Guerra Simões; Silva, Gabriela Lucas da; Manfredini, Vanusa; Vargas, Carmen Regla; Gnoatto, Simone Cristina Baggio; Oliveira, Jarbas Rodrigues de; Gosmann, Grace (2012) [Artículo de periódico]
      Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities ...

    • Phenotype-oriented NGS panels for mucopolysaccharidoses : validation and potential use in the diagnostic flowchart 

      Fachin, Ana Carolina Brusius; Siebert, Marina; Leão, Delva Pereira; Málaga, Diana Elizabeth Rojas; Pasqualim, Gabriela; Trapp, Franciele Barbosa; Matte, Ursula da Silveira; Giugliani, Roberto; Leistner-Segal, Sandra (2019) [Artículo de periódico]
      Mucopolysaccharidosis (MPS) are a group of rare genetic disorders caused by deficiency in the activity of specific lysosomal enzymes required for the degradation of glycosaminoglycans (GAGs). A defect in the activity of ...

    • Phenotyping and genotyping methods applied to investigate the relatedness of brazilian isolates of enterobacter cloacae 

      Darini, A.L.C.; Magalhães, V.D.; Levy, C.L.; Barth, Afonso Luis; Coscina, A.L. (1999) [Artículo de periódico]
      In order to evaluate the resolving power of several typing methods to identify relatedness among Brazilian strains of Enterobacter cloacae, we selected twenty isolates from different patients on three wards of a University ...

    • Phenylketonuria and gut microbiota : a controlled study based on next-generation sequencing 

      Oliveira, Felipe Pinheiro de; Mendes, Roberta Hack; Dobbler, Priscila Caroline Thiago; Mai, Volker; Pylro, Victor Satler; Waugh, Sheldon G.; Vairo, Filippo Pinto e; Refosco, Lilia Farret; Roesch, Luiz Fernando Wurdig; Schwartz, Ida Vanessa Doederlein (2016) [Artículo de periódico]
      Phenylketonuria (PKU) is an inborn error of metabolism associated with high blood levels of phenylalanine (Phe). A Phe-restricted diet supplemented with L-amino acids is the main treatment strategy for this disease; if ...

    • PH e titrabilidade ácida de sucos artificiais de limão 

      Corso, Ana Carolina; Hugo, Fernando Neves; Padilha, Dalva Maria Pereira (2002) [Artículo de periódico]

    • Philadelphia-negative chronic myeloproliferative neoplasms 

      Bittencourt, Rosane Isabel; Vassallo, Jose; Chauffaille, Maria de Lourdes Lopes Ferrari; Xavier, Sandra Guerra; Pagnano, Katia Borgia Barbosa; Nascimento, Ana Clara Kneese Virgilio do; Souza, Cármino Antônio de; Chiattone, Carlos Sérgio (2012) [Artículo de periódico]
      Chronic myeloproliferative diseases without the Philadelphia chromosome marker (Ph-), although first described 60 years ago, only became the subject of interest after the turn of the millennium. In 2001, the World Health ...

    • Phonemic verbal fluency and severity of anxiety disorders in young children 

      Toazza, Rudineia; Salum Junior, Giovanni Abrahão; Sousa, Diogo Araújo de; Jarros, Rafaela Behs; Salles, Jerusa Fumagalli de; Manfro, Gisele Gus (2016) [Artículo de periódico]
      Introduction: Previous studies have implicated impaired verbal fluency as being associated with anxiety disorders in adolescents. Objectives: To replicate and extend previously reported evidence by investigating whether ...

    • Phonetic transcription of spontaneous children's speech with the aid of software : a systematic review 

      Caumo, Débora Tomazi Moreira; França, Marcio Pezzini; Silva, Clecio Homrich da (2022) [Artículo de periódico]
      O objetivo do estudo foi identificar, sintetizar e classificar os softwares atualmente disponíveis que podem auxiliar na tarefa de transcrição fonética da fala espontânea de pré-escolares, para avaliar o desenvolvimento ...

    • A phosphodiesterase 4-controlled switch between memory extinction and strengthening in the hippocampus 

      Roesler, Rafael; Reolon, Gustavo Kellermann; Maurmann, Natasha; Schwartsmann, Gilberto; Schroder, Nadja; Amaral, Olavo Bohrer; Valvassori, Samira da Silva; Quevedo, João Luciano de (2014) [Artículo de periódico]
      Established fear-related memories can undergo phenomena such as extinction or reconsolidation when recalled. Extinction probably involves the creation of a new, competing memory trace that decreases fear expression, whereas ...

    • Photodegradation of sparfloxacin and isolation of its degradation products by preparative HPLC 

      Salgado, H.R.N.; Moreno, Paulo Roberto Hrihorowitsch; Braga, A.L.; Schapoval, Elfrides Eva Scherman (2005) [Artículo de periódico]
      Sparfloxacin, a third generation fluoroquinolone derivative,is a potent antibacterial agent active against a wide range ofGram-positive and Gram-negative organisms including Streptococcus pneumoniae, Staphylococcus aureus, ...