Navegação Ciências Biológicas por Autor "Wajner, Moacir"
Resultados 1-17 de 17
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Acidúrias orgânicas : diagnóstico em pacientes de alto risco no Brasil
Wajner, Moacir; Barschak, Alethea Gatto; Luft, Ana Paula; Pires, Ricardo Flores; Grillo, Eugênio; Lohr, Alfredo; Funayama, Carolina Araújo Rodrigues; Sanseverino, Maria Teresa Vieira; Giugliani, Roberto; Vargas, Carmen Regla (2001) [Artigo de periódico]Objetivo: o objetivo deste trabalho foi o de verificar a prevalência das acidúrias orgânicas em pacientes brasileiros de alto risco. Métodos: técnicas laboratoriais para a detecção e quantificação de ácidos orgânicos por ... -
Acute liver failure induces glial reactivity, oxidative stress and impairs brain energy metabolism in rats
Guazzelli, Pedro Arend; Santos, Giordano Fabricio Cittolin; Martins, Leo Anderson Meira; Grings, Mateus; Nonose, Yasmine; Lazzarotto, Gabriela; Nogara, Daniela Albugeri; Silva, Jussemara Souza da; Fontella, Fernanda Urruth; Wajner, Moacir; Leipnitz, Guilhian; Souza, Diogo Onofre Gomes de; Assis, Adriano Martimbianco de (2020) [Artigo de periódico]Acute liver failure (ALF) implies a severe and rapid liver dysfunction that leads to impaired liver metabolism and hepatic encephalopathy (HE). Recent studies have suggested that several brain alterations such as astrocytic ... -
Aplicação de um protocolo clínico-laboratorial para identificação de erros inatos do metabolismo em crianças gravemente enfermas
Sanseverino, Maria Teresa Vieira; Wajner, Moacir; Giugliani, Roberto (2000) [Artigo de periódico]Objetivo: O objetivo deste trabalho foi aplicar um protocolo para a investigação de Erros Inatos do Metabolismo (EIM) em crianças gravemente enfermas. Métodos: Trata-se de um estudo transversal envolvendo 46 crianças com ... -
Chronic postnatal administration of methylmalonic acid provokes a decrease of myelin content and ganglioside N-acetylneuramic acid concentration in cerebrum of young rats
Brusque, Ana Maria; Rotta, Liane Nanci; Pettenuzzo, Letícia Ferreira; Junqueira, Debora; Schwarzbold, Carolina Vargas; Wyse, Angela Terezinha de Souza; Wannmacher, Clovis Milton Duval; Dutra Filho, Carlos Severo; Wajner, Moacir (2001) [Artigo de periódico]Levels of methylmalonic acid (MMA) comparable to those of human methylmalonic acidemia were achieved in blood (2-2.5 mmol/l) and brain (1.35 µmol/g) of rats by administering buffered MMA, pH 7.4, subcutaneously twice a day ... -
Clinical and biochemical findings in 7 patients with X-linked adrenoleukodystrophy treated with Lorenzo's oil
Vargas, Carmen Regla; Barschak, Alethea Gatto; Coelho, Daniela de Moura; Furlanetto, Vivian; Souza, Carolina Fischinger Moura de; Karam, Simone de Menezes; Jardim, Laura Bannach; Wajner, Moacir; Giugliani, Roberto (2000) [Artigo de periódico]A adrenoleucodistrofia ligada ao X (X-ALD) é uma desordem hereditária do metabolismo peroxissomal, bioquimicamente caracterizada pelo acúmulo de ácidos graxos de cadeia muito longa (‘very long chain fatty acids”- VLCFA) ... -
DNA damage in homocystinuria : 8-oxo-, 8-dihydro-2’-deoxyguanosine levels in cystathionine-β-synthase deficient patients and the in vitro protective effect of N-acetyl-L-cysteine
Vanzin, Camila Simioni; Mescka, Caroline Paula; Marchetti, Desirèe Padilha; Donida, Bruna; Deon, Marion; Jacques, Carlos Eduardo Diaz; Hauschild, Tatiane Cristina; Faverzani, Jéssica Lamberty; Hauschild, Tatiane Cristina; Moura, Dinara Jaqueline; Saffi, Jenifer; Coelho, Daniella de Moura; Wajner, Moacir; Wyse, Angela Terezinha de Souza; Vargas, Carmen Regla (2018) [Artigo de periódico]Introduction: Homocysteine (Hcy) tissue accumulation occurs in a metabolic disease characterized biochemically by cystathionine β-synthase (CBS) deficiency and clinically by mental retardation, vascular problems, and ... -
Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway
Vizuete, Adriana Fernanda Kuckartz; Fróes, Fernanda Carolina Telles da Silva; Seady, Marina Pedra; Boeckel, Caroline Zanotto de; Bobermin, Larissa Daniele; Roginski, Ana Cristina; Wajner, Moacir; Quincozes-Santos, André; Goncalves, Carlos Alberto Saraiva (2022) [Artigo de periódico]Neuroinflammation is a common feature during the development of neurological disorders and neurodegenerative diseases, where glial cells, such as microglia and astrocytes, play key roles in the activation and maintenance ... -
Effect of FSH and insulin on lipogenesis in cultures of Sertoli cells from immature rats
Guma, Fátima Theresinha Costa Rodrigues; Wajner, Moacir; Martini, Lucia Helena; Bernard, Elena Aida (1997) [Artigo de periódico]Follicle-stimulating hormone (FSH) and insulin regulate glycide metabolism in Sertoli cells, thus stimulating lactate production. These stimulatory effects of FSH and insulin do not require protein synthesis, suggesting a ... -
Increased susceptibility to quinolinic acid-induced seizures and long-term changes in brain oscillations in an animal model of glutaric acidemia type I
Caus, Letícia Barbieri; Pasquetti, Mayara Vendramin; Seminotti, Bianca; Woontner, Michael; Wajner, Moacir; Calcagnotto, Maria Elisa (2022) [Artigo de periódico]Glutaric acidemia type I (GA-I) is an inborn error of metabolism of lysine, hydroxylysine, and tryptophan, caused by glutaryl-CoA-dehydrogenase (GCDH) deficiency, characterized by the buildup of toxic organic acids ... -
Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain
Silva, Alexandre Rodrigues da; Ruschel, Cristiano; Helegda, Celio; Wyse, Angela Terezinha de Souza; Wannmacher, Clovis Milton Duval; Wajner, Moacir; Dutra Filho, Carlos Severo (2001) [Artigo de periódico]2-Hydroxybutyric acid appears at high concentrations in situations related to deficient energy metabolism (e.g., birth asphyxia) and also in inherited metabolic diseases affecting the central nervous system during neonatal ... -
Investigação de erros inatos do metabolismo
Wajner, Moacir; Vargas, Carmen Regla; Burin, Maira Graeff; Giugliani, Roberto; Coelho, Janice Carneiro (2001) [Artigo de periódico]Os erros inatos do metabolismo são doenças metabólicas hereditárias individualmente raras, mas que em seu conjunto apresentam uma incidência aproximada de pelo menos 1 caso para cada mil nascimentos. O presente trabalho ... -
Monitoring of phenylalanine levels in patients with phenylketonuria using dried blood spots : a comparison of two methods
Sebastião, Fernanda Medeiros; Burin, Maira Graeff; Civallero, Gabriel Eduardo Santiago; Tirelli, Kristiane Michelin; Sitta, Angela; Coelho, Daniella de Moura; Vargas, Carmen Regla; Wajner, Moacir; Giugliani, Roberto; Bitencourt, Fernanda Hendges de; Schwartz, Ida Vanessa Doederlein (2020) [Artigo de periódico]Phenylketonuria (PKU) is caused by deficient activity of phenylalanine hydroxylase (PAH), responsible for the conversion of phenylalanine (Phe) to tyrosine (Tyr). Monitoring of patients with PKU requires the measurement ... -
Nova era da medicina genômica
Wajner, Moacir; Giugliani, Roberto (2001) [Texto de apresentação/encerramento]Resumo não disponível -
Plinia trunciflora extract administration prevents HI-induced oxidative stress, inflammatory response, behavioral impairments, and tissue damage in rats
Carvalho, Andrey Vinicios Soares; Ribeiro, Rafael Teixeira; Duran Carabali, Luz Elena; Martini, Ana Paula Rodrigues; Hoeper, Eduarda de Souza; Sanches, Eduardo Farias; Konrath, Eduardo Luis; Dalmaz, Carla; Wajner, Moacir; Netto, Carlos Alexandre (2022) [Artigo de periódico]The disruption of redox homeostasis and neuroinflammation are key mechanisms in the pathogenesis of brain hypoxia–ischemia (HI); medicinal plants have been studied as a therapeutic strategy, generally associated with the ... -
Resveratrol protects C6 astrocyte cell line against hydrogen peroxide-induced oxidative stress through heme oxygenase 1
Quincozes-Santos, André; Bobermin, Larissa Daniele; Latini, Alexandra Susana; Wajner, Moacir; Souza, Diogo Onofre Gomes de; Goncalves, Carlos Alberto Saraiva; Gottfried, Carmem Juracy Silveira (2013) [Artigo de periódico]Resveratrol, a polyphenol presents in grapes and wine, displays antioxidant and anti-inflammatory properties and cytoprotective effect in brain pathologies associated to oxidative stress and neurodegeneration. In previous ... -
Screening for organic acidurias and aminoacidopathies in high-risk Brazilian patients : eleven-year experience of a reference center
Wajner, Moacir; Sitta, Angela; Kayser, Aline; Deon, Marion; Groehs, Ana Carolina; Coelho, Daniella de Moura; Vargas, Carmen Regla (2019) [Artigo de periódico]Organic acidurias and aminoacidopathies are groups of frequent inborn errors of metabolism (IEMs), which are caused by mutations in specific genes that lead to loss of protein/enzyme or transport function with important ... -
Selective screening of 18,000 high-risk brazilian patients for the detection of inborn errors of metabolism
Burin, Maira Graeff; Coelho, Janice Carneiro; Wajner, Moacir; Vargas, Carmen Regla; Souza, Fernanda Timm Seabra; Giugliani, Roberto (2001) [Artigo de periódico]OBJECTIVE: The number of diagnosed inborn errors of metabolism (IEM) is growing constantly due to the improvement and widespread availability of analytical techniques. In 1982, a laboratory for the detection of IEM was set ...