• Obesity drives adipose-derived stem cells into a senescent and dysfunctional phenotype associated with P38MAPK/NF-KB axis 

      Grun, Lucas Kich; Maurmann, Rafael Moura; Scholl, Juliete Nathali; Fogaça, M. E.; Schmitz, Carine Raquel Richter; Dias, Camila kehl; Gasparotto, Juciano; Padoin, Alexandre Vontobel; Mottin, Cláudio Corá; Klamt, Fabio; Figueiró, Fabrício; Jones, Marcus Herbert; Chiela, Eduardo Cremonese Filippi; Guma, Fátima Theresinha Costa Rodrigues; Barbé-Tuana, Florencia María (2023) [Artículo de periódico]
      Background: Adipose-derived stem cells (ADSC) are multipotent cells implicated in tissue homeostasis. Obesity represents a chronic inflammatory disease associated with metabolic dysfunction and age-related mechanisms, with ...
    • Shorter telomeres in children with severe asthma, an indicative of accelerated aging 

      Barbé-Tuana, Florencia María; Grun, Lucas Kich; Lima, Vinícius Pierdoná; Parisi, Mariana Migliorini; Friedrich, Frederico Orlando; Guma, Fátima Theresinha Costa Rodrigues; Pinto, Leonardo Araujo; Stein, Renato Tetelbom; Pitrez, Paulo Marcio Condessa; Jones, Marcus Herbert (2021) [Artículo de periódico]
      Severe therapy-resistant asthma (STRA) is closely associated with distinct clinical and inflammatory pheno-endotypes, which may contribute to the development of age-related comorbidities. Evidence has demonstrated a ...