Listar Ciencias Biologicas por título
Mostrando ítems 1328-1347 de 3081
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Genome mining for antimicrobial compounds in wild marine animals-associated Enterococci
(2021) [Artículo de periódico]New ecosystems are being actively mined for new bioactive compounds. Because of the large amount of unexplored biodiversity, bacteria from marine environments are especially promising. Further, host-associated microbes are ... -
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
(2023) [Artículo de periódico]Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals ... -
Genome-wide analysis of the Glycerol-3-Phosphate Acyltransferase (GPAT) gene family reveals the evolution and diversification of plant GPATs
(2018) [Artículo de periódico]sn-Glycerol-3-phosphate 1-O-acyltransferase (GPAT) is an important enzyme that catalyzes the transfer of an acyl group from acyl-CoA or acyl-ACP to the sn-1 or sn-2 position of sn-glycerol-3-phosphate (G3P) to generate ... -
Genome-wide annotation of the soybean WRKY family and functional characterization of genes involved in response to Phakopsora pachyrhizi infection
(2014) [Artículo de periódico]Background: Many previous studies have shown that soybean WRKY transcription factors are involved in the plant response to biotic and abiotic stresses. Phakopsora pachyrhizi is the causal agent of Asian Soybean Rust, one ... -
A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
(2016) [Artículo de periódico]We report a genome-wide association scan for facial features in B6,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P valueso5 10 8) at single-nucleotide polymorphisms ... -
Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans
(2018) [Artículo de periódico]Hair plays an important role in primates and is clearly subject to adaptive selection. While humans have lost most facial hair, eyebrows are a notable exception. Eyebrow thickness is heritable and widely believed to be ... -
Genome-wide association study identifies genetic factors that modify age at onset in Machado-Joseph disease
(2020) [Artículo de periódico]Machado-Joseph disease (MJD/SCA3) is the most common form of dominantly inherited ataxia worldwide. The disorder is caused by an expanded CAG repeat in the ATXN3 gene. Past studies have revealed that the length of the ... -
Genome-wide DNA methylation analysis of Metarhizium anisopliae during tick mimicked infection condition
(2019) [Artículo de periódico]Background: The Metarhizium genus harbors important entomopathogenic fungi. These species have been widely explored as biological control agents, and strategies to improve the fungal virulence are under investigation. Thus, ... -
Genome-wide interrogation of structural variation reveals novel African-specifc prostate cancer oncogenic drivers
(2022) [Artículo de periódico]Background: African ancestry is a signifcant risk factor for advanced prostate cancer (PCa). Mortality rates in subSaharan Africa are 2.5-fold greater than global averages. However, the region has largely been excluded ... -
Genomic analyses and transcriptional profiles of the glycoside hydrolase family 18 genes of the entomopathogenic fungus Metarhizium anisopliae
(2014) [Artículo de periódico]Fungal chitin metabolism involves diverse processes such as metabolically active cell wall maintenance, basic nutrition, and different aspects of virulence. Chitinases are enzymes belonging to the glycoside hydrolase family ... -
Genomic analysis in the clinic : benefits and challenges for health care professionals and patients in Brazil
(2015) [Artículo de periódico]Despite significant advances in the diagnosis and treatment of genetic diseases in the last two decades, there is still a significant proportion where a causative mutation cannot be identified and a definitive genetic ... -
Genomic analysis of Brazilian patients with fabry disease
(2007) [Artículo de periódico]Fabry disease is an X-linked lysosomal disorder due to α-galactosidase A deficiency that causes storage of globotriaosylceramide. The gene coding for this lysosomal enzyme is located on the long arm of the X chromosome, ... -
Genomic characterization of novel circular ssDNA viruses from insectivorous bats in southern Brazil
(2015) [Artículo de periódico]Circoviruses are highly prevalent porcine and avian pathogens. In recent years, novel circular ssDNA genomes have recently been detected in a variety of fecal and environmental samples using deep sequencing approaches. In ... -
Genomic epidemiology of SARS-CoV-2 in Esteio, Rio Grande do Sul, Brazil
(2021) [Artículo de periódico]Background: Brazil is the third country most affected by Coronavirus disease-2019 (COVID-19), but viral evolution in municipality resolution is still poorly understood in Brazil and it is crucial to understand the epidemiology ... -
Genomic epidemiology reveals the circulation of the Chikungunya virus east/central/south african lineage in Tocantins State, north Brazil
(2022) [Artículo de periódico]The chikungunya virus (CHIKV) is a mosquito-borne virus of the family Togaviridae transmitted to humans by Aedes spp. mosquitoes. In Brazil, imported cases have been reported since June 2014 through two independent ... -
Genomic epidemiology unveils the dynamics and spatial corridor behind the Yellow Fever virus outbreak in Southern Brazil
(2023) [Artículo de periódico]Despite the considerable morbidity and mortality of yellow fever virus (YFV) infections in Brazil, our understanding of disease outbreaks is hampered by limited viral genomic data. Here, through a combination of phylogenetic ... -
Genomic insights into the versatility of the plant growth-promoting bacterium Azospirillum amazonense
(2011) [Artículo de periódico]Background: The species Azospirillum amazonense belongs to a well-known genus of plant growth-promoting bacteria. This bacterium is found in association with several crops of economic importance; however, there is a lack ... -
Genomic organization of microsatellites and LINE-1-like retrotransposons: evolutionary implications for Ctenomys minutus (Rodentia: Ctenomyidae) Cytotypes
(2022) [Artículo de periódico]The Neotropical underground rodents of the genus Ctenomys (Rodentia: Ctenomyidae) comprise about 65 species, which harbor the most significant chromosomal variation among mammals (2n = 10 to 2n = 70). Among them, C. minutus ... -
Genomic rearrangements in BRCA1 and BRCA2 : a literature review
(2009) [Artículo de periódico]Women with mutations in the breast cancer genes BRCA1 or BRCA2 have an increased lifetime risk of developing breast, ovarian and other BRCA-associated cancers. However, the number of detected germline mutations in families ... -
Genotoxic effect of alkaloids
(1991) [Artículo de periódico]Because of the increased use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and ...
