Browsing Biological Sciences by Title
Now showing items 1712-1731 of 3025
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Master regulators connectivity map : a transcription factors-centered approach to drug repositioning
(2018) [Journal article]Drug discovery is a very expensive and time-consuming endeavor. Fortunately, recent omics technologies and Systems Biology approaches introduced interesting new tools to achieve this task, facilitating the repurposing of ... -
Maternal drinking behavior and fetal alcohol spectrum disorders in adolescents with criminal behavior in southern Brazil
(2012) [Journal article]Prenatal alcohol exposure can have serious and permanent adverse effects. The developing brain is the most vulnerable organ to the insults of prenatal alcohol exposure. A behavioral phenotype of prenatal alcohol exposure ... -
Maternal high-salt diet alters redox state and mitochondrial function in newborn rat offspring's brain
(2018) [Journal article]Excessive salt intake is a common feature of Western dietary patterns, and has been associated with important metabolic changes including cerebral redox state imbalance. Considering that little is known about the effect ... -
Maternal outcomes and risk factors for COVID-19 severity among pregnant women
(2021) [Journal article]Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study ... -
Maternity in the Brazilian CV Lattes : when will it become a reality?
(2021) [Introductory and closing remarks]Resumo não disponível -
Matrix metalloproteinase gene polymorphisms and susceptibility to systemic sclerosis
(2016) [Journal article]The major pathological hallmark of the systemic sclerosis (SSc) is skin and internal organ fibrosis, which results from normal tissue architecture alterations and extracellular matrix (ECM) protein deposition. ECM components ... -
Matrix metalloproteinase gene polymorphisms in patients with coronary artery disease
(2007) [Journal article]Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of atherosclerosis, the pathology underlying the majority of coronary artery disease (CAD). In this study we tested the hypothesis that polymorphic ... -
Matrix stiffness mechanically conditions EMT and migratory behavior of oral squamous cell carcinoma
(2019) [Journal article]Tumors are composed of heterogeneous phenotypes, each having different sensitivities to the microenvironment. One microenvironment characteristic – matrix stiffness – helps to regulate malignant transformation and invasion ... -
Maturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in rats
(2020) [Journal article]Studies have shown that neonate rodents exhibit high ability to learn a preference for novel odors associated with thermotactile stimuli that mimics maternal care. Artificial odors paired with vigorous strokes in rat pups ... -
May polyester with collagen coating mesh decrease the rate of intraperitoneal adhesions in incisional hernia repair?
(2013) [Journal article]Background - Among meshes used in incisional hernias in open technique repair, the polypropylene is the most commonly used due to flexibility, cellular growth stimulation, satisfactory inflammatory response, easy manipulation ... -
MBL2 gene polymorphisms and its relation to infection in Brazilian systemic lupus erythematosus patients : a 10-years followup study
(2022) [Journal article]Introduction: Systemic lupus erythematosus (SLE) is a multifactorial disease and MBL2 genetic variants, which are associated to differential peripheral MBL levels, potentially affect its etiology and increase infection ... -
MBSP1: a biosurfactant protein derived from a metagenomic library with activity in oil degradation
(2020) [Journal article]Microorganisms represent the most abundant biomass on the planet; however, because of several cultivation technique limitations, most of this genetic patrimony has been inaccessible. Due to the advent of metagenomic ... -
Measurement of sulfatides in the amniotic fluid supernatant : a useful tool in the prenatal diagnosis of metachromatic leukodystrophy
(2022) [Journal article]Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal disorder caused by deficiency of arylsulfatase A (ARSA), leading to an accumulation of sulfatides. Sulfatides have been quantified in urine, dried blood ... -
Meat market reaction towards mass media and science communication on bovine spongiform encephalopathy
(2013) [Journal article]This study assesses the correlation between reports on food risk published in scientific journals and in the printed mass media and changes in the meat market. It focuses on the case of bovine spongiform encephalopathy ... -
Mecanismos moleculares no hirsutismo : expressão gênica de enzimas do metabolismo androgênico no folículo piloso e associação com o diagnóstico etiológico
(2003) [Journal article]Androgens are the main hormonal regulators of human hair growth and they are related to clinical conditions such as hirsutism. The aim of this study was to analyze the gene expression of androgen receptor (AR), type 1 and ... -
Mechanisms underlying the antiproliferative effects of a series of quinoxaline-derived chalcones
(2017) [Journal article]The present study aimed to characterize the effects of quinoxaline-derived chalcones, designed on the basis of the selective PI3Kγ inhibitor AS605240, in oral cancer cells. Three lead compounds, namely N9, N17 and N23, ... -
Medical Genetics : special issue dedicated to the 35th anniversary of the Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Brazil
(2019) [Introductory and closing remarks] -
Medicamentos de alto custo para doenças raras no Brasil : o exemplo das doenças lisossômicas
(2010) [Journal article]Este artigo aborda, de forma crítica, aspectos das políticas públicas brasileiras para medicamentos, com ênfase nos de alto custo dirigidos às doenças raras. As doenças lisossômicas foram utilizadas como exemplo pela sua ... -
Melanoma hereditário : prevalência de fatores de risco em um grupo de pacientes no Sul do Brasil
(2004) [Journal article]FUNDAMENTOS - Aproximadamente 10% dos casos de melanoma são atribuíveis a mutações em genes de predisposição, sendo, portanto, hereditários. OBJETIVOS - Este estudo avalia a prevalência de fatores de risco para melanoma ... -
Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia : a phase II, randomized, double-dummy, controlled trial
(2014) [Journal article]Background: Central disinhibition is a mechanism involved in the physiopathology of fibromyalgia. Melatonin can improve sleep quality, pain and pain threshold. We hypothesized that treatment with melatonin alone or in ...