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dc.contributor.authorDartora, William Jonespt_BR
dc.contributor.authorMaestri, Marcelo Kriegerpt_BR
dc.contributor.authorSchmidt, Maria Inêspt_BR
dc.contributor.authorDuncan, Bruce Bartholowpt_BR
dc.contributor.authorChambless, Lloyd Ellwoodpt_BR
dc.contributor.authorKlein, Ronaldpt_BR
dc.contributor.authorMeuer, Stacy M.pt_BR
dc.contributor.authorLuft, Vivian Cristinept_BR
dc.date.accessioned2019-02-20T02:36:23Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn1516-3180pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/188868pt_BR
dc.description.abstractBACKGROUND: Investigation of alterations to retinal microvasculature may contribute towards understanding the role of such changes in the pathophysiology of several chronic non-communicable diseases. The objective here was to evaluate the validity and reproducibility of retinal arteriole and venule diameter measurements made by Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) graders. DESIGN AND SETTING: Cross-sectional study at six teaching and research institutions. METHODS: To evaluate validity, each of 25 retinal images from the University of Wisconsin (gold standard) was measured by five ELSA-Brasil graders. To evaluate reproducibility, 105 images across the spectrum of vessel diameters were selected from 12,257 retinal images that had been obtained between 2010 and 2012, and each image was reexamined by the same grader and by an independent grader. All measurements were made using the Interactive Vessel Analysis (IVAN) software. Bland-Altman plots, paired t tests and intraclass correlation coefficients (ICCs) were analyzed. RESULTS: Mean differences between ELSA-Brasil and gold-standard readings were 0.16 μm (95% CI -0.17‑0.50; P = 0.31) for central retinal artery equivalent (CRAE), -0.21 μm (95% CI -0.56-0.14; P = 0.22) for central retinal vein equivalent (CRVE) and 0.0005 (95% CI -0.008-0.009; P = 0.55) for arteriole/venule ratio (AVR). Intragrader ICCs were 0.77 (95% CI 0.67-0.86) for CRAE, 0.90 (95% CI 0.780.96) for CRVE and 0.70 (0.55‑0.83) for AVR. Intergrader ICCs were 0.75 (95% CI 0.64-0.85) for CRAE, 0.90 (95% CI 0.79-0.96) for CRVE and 0.68 (95% CI 0.55‑0.82) for AVR. CONCLUSIONS: Retinal microvascular diameter measurements are valid and present moderate to high intra and intergrader reproducibility in ELSA-Brasil.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofSão Paulo medical journal. São Paulo. vol. 136, no. 4 (July/Aug. 2018), p. 276-286pt_BR
dc.rightsOpen Accessen
dc.subjectMicrovesselsen
dc.subjectMicrovasospt_BR
dc.subjectRetinal arteryen
dc.subjectArtéria retinianapt_BR
dc.subjectRetinal veinen
dc.subjectVeia retinianapt_BR
dc.subjectAntropometriapt_BR
dc.subjectReproducibility of resultsen
dc.subjectEstudo de validaçãopt_BR
dc.titleValidity and reproducibility of retinal arteriole and venule diameter measurements : ELSA-Brasil study : a cross-sectional studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001085300pt_BR
dc.type.originNacionalpt_BR


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