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dc.contributor.authorMotta, Guilherme Langpt_BR
dc.contributor.authorSouza, Pablo Cambesespt_BR
dc.contributor.authorSantos, Emanuel Burck dospt_BR
dc.contributor.authorBona, Silvia Reginapt_BR
dc.contributor.authorSchaefer, Pedro Guilhermept_BR
dc.contributor.authorLima, Caetano Araujo Torrespt_BR
dc.contributor.authorMarroni, Norma Anair Possapt_BR
dc.contributor.authorCorso, Carlos Otaviopt_BR
dc.date.accessioned2018-10-27T03:12:51Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn0102-8650pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/184131pt_BR
dc.description.abstractPurpose: To evaluate whether combining hypothermia and remote ischemic preconditioning (RIPC) results in protection from ischemia-reperfusion (IR). Methods: Thirty-two Wistar rats underwent right nephrectomy and were randomly assigned to four experimental protocols on the left kidney: warm ischemia (group 1), cold ischemia (group 2), RIPC followed by warm ischemia (group 3), and RIPC followed by cold ischemia (group 4). After 240 minutes of reperfusion, histological changes in the left kidney, as well as lipid peroxidation and antioxidant enzyme activity, were analyzed. The right kidney was used as the control. Serum creatinine was collected before and after the procedures. Results: RIPC combined with hypothermia during IR experiments revealed no differences on interventional groups regarding histological changes (p=0.722). Oxidative stress showed no significant variations among the groups. Lower serum creatinine at the end of the procedure was seen in animals exposed to hypothermia (p<0.001). Conclusions: Combination of RIPC and local hypothermia provides no renal protection in IR injury. Hypothermia preserves renal function during ischemic events. Furthermore, RIPC followed by warm IR did not show benefits compared to warm IR alone or controls in our experimental protocol.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofActa cirúrgica brasileira. São Paulo. Vol. 33, n. 5 (2018), p. 396-407pt_BR
dc.rightsOpen Accessen
dc.subjectPrecondicionamento isquêmicopt_BR
dc.subjectIschemiaen
dc.subjectReperfusion Injuryen
dc.subjectHipotermia induzidapt_BR
dc.subjectIsquemia friapt_BR
dc.subjectHypothermiaen
dc.subjectFree Radicalsen
dc.subjectIsquemia quentept_BR
dc.subjectOxidative Stressen
dc.subjectTraumatismo por reperfusãopt_BR
dc.subjectRatsen
dc.subjectModelos animais de doençaspt_BR
dc.subjectRatos Wistarpt_BR
dc.titleEffects of remote ischemic preconditioning and topical hypothermia in renal ischemia-reperfusion injury in ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001078463pt_BR
dc.type.originNacionalpt_BR


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