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dc.contributor.authorFagundes, Nelson Jurandi Rosapt_BR
dc.contributor.authorRibeiro, Alice Taglianipt_BR
dc.contributor.authorRubicz, Rohinapt_BR
dc.contributor.authorTarskaia, Larissapt_BR
dc.contributor.authorCrawford, Michael H.pt_BR
dc.contributor.authorSalzano, Francisco Mauropt_BR
dc.contributor.authorBonatto, Sandro Luispt_BR
dc.date.accessioned2018-10-23T02:41:33Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/183915pt_BR
dc.description.abstractIn spite of many genetic studies that contributed for a deep knowledge about the peopling of the Americas, no consensus has emerged about important parameters such as the effective size of the Native Americans founder population. Previous estimates based on genomic datasets may have been biased by the use of admixed individuals from Latino populations, while other recent studies using samples from Native American individuals relied on approximated analytical approaches. In this study we use resequencing data for nine independent regions in a set of Native American and Siberian individuals and a full-likelihood approach based on isolation-with-migration scenarios accounting for recent flow between Asian and Native American populations. Our results suggest that, in agreement with previous studies, the effective size of the Native American population was small, most likely in the order of a few hundred individuals, with point estimates close to 250 individuals, even though credible intervals include a number as large as ~4,000 individuals. Recognizing the size of the genetic bottleneck during the peopling of the Americas is important for determining the extent of genetic markers needed to characterize Native American populations in genome- wide studies and to evaluate the adaptive potential of genetic variants in this population.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Ribeirão Preto, SP. Vol. 41, no. 1 suppl (mar. 2018), p. 206-214.pt_BR
dc.rightsOpen Accessen
dc.subjectIsolation with Migration modelen
dc.subjectDiversidade genéticapt_BR
dc.subjectCoalescent analysisen
dc.subjectGenética de populaçõespt_BR
dc.subjectNative Siberiansen
dc.subjectPovoamentopt_BR
dc.subjectAmeríndiospt_BR
dc.titleHow strong was the bottleneck associated to the peopling of the Americas? new insights from multilocus sequence datapt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001073249pt_BR
dc.type.originNacionalpt_BR


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