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dc.contributor.authorFernandes, Sabrina A.pt_BR
dc.contributor.authorBona, Silvia Reginapt_BR
dc.contributor.authorCerski, Carlos Thadeu Schmidtpt_BR
dc.contributor.authorMarroni, Norma Anair Possapt_BR
dc.contributor.authorMarroni, Claudio Augustopt_BR
dc.date.accessioned2018-10-23T02:41:29Zpt_BR
dc.date.issued2016pt_BR
dc.identifier.issn0004-2803pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/183903pt_BR
dc.description.abstractBackground - The inherent complications of cirrhosis include protein-calorie malnutrition and micronutrient deficiencies. Changes in taste are detrimental to the nutritional status, and the mechanism to explain these changes is not well documented in the cirrhotic patients. Objective - To evaluate the taste buds of cirrhotic rats. Methods - Fourteen male Wistar rats were evaluated. After 16 weeks, the liver was removed to histologically diagnose cirrhosis, and blood was collected to perform liver integrity tests. The tongue was removed for histological examination and immunohistochemistry using antibodies against protein gene product PGP 9.5 and the sweet taste receptors T1R2 and T1R3. Morphological changes were determined by scanning electron microscopy. Serum zinc levels were measured. Results - The cirrhotic animals, but not the control animals, exhibited zinc deficiency. In both groups, there was positive immunoreactivity for type II and III cells and T1R2 receptors. The cirrhotic animals had no immunoreactivity for T1R3 receptors. Scanning electron microscopy analysis of the cirrhotic group revealed a uniform tapering of the gustatory papillae. Conclusion - In conclusion the experimental cirrhosis model mimicked the biochemical and histological parameters of human cirrhosis, therefore enabling a study of the gustatory papillae and taste buds.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofArquivos de gastroenterologia. São Paulo. Vol. 53, n. 4 (out./nov. 2016), p. 278-284pt_BR
dc.rightsOpen Accessen
dc.subjectLiver cirrhosisen
dc.subjectPapilas gustativaspt_BR
dc.subjectDeficiência de zincopt_BR
dc.subjectTaste budsen
dc.subjectMalnutritionen
dc.subjectCirrose hepáticapt_BR
dc.subjectZincen
dc.subjectImuno-histoquímicapt_BR
dc.subjectAnimaispt_BR
dc.subjectMicroscopy electron scanningen
dc.subjectMorphological and microscopic findingsen
dc.subjectRatos Wistarpt_BR
dc.titleAlteration of taste buds in experimental cirrhosis. Is there correlation with human hypogeusia?pt_BR
dc.title.alternativeAlteração de paladar em um modelo experimental de cirrose. Existe correlação com hipogeusia humana? pt
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001070472pt_BR
dc.type.originNacionalpt_BR


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