Mostrar el registro sencillo del ítem

dc.contributor.authorTeixeira, Uirá Fernandespt_BR
dc.contributor.authorIzaguirre, Andréa Gomes Coelhopt_BR
dc.contributor.authorMachry, Mayara Christpt_BR
dc.contributor.authorCerski, Carlos Thadeu Schmidtpt_BR
dc.contributor.authorBrandao, Ajacio Bandeira de Mellopt_BR
dc.contributor.authorFontes, Paulo Roberto Ottpt_BR
dc.date.accessioned2018-10-23T02:41:29Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn0004-2803pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/183902pt_BR
dc.description.abstractBackground - Discovery and incorporation of biomarker panels to cancer studies enabled the understanding of genetic variation and its interference in carcinogenesis at molecular level. The potential association between single nucleotide polymorphism (SNP) 309 and increased development of tumors, such as hepatocellular carcinoma, has been subject to several studies. This is the first study on this association conducted in Brazil. Methods - 62 cases of cirrhotic patients with hepatocellular carcinoma surgically treated by partial hepatectomy (HPT) or by liver transplantation (LTX) from 2000 to 2009 at Santa Casa Hospital Complex, in the city of Porto Alegre, were retrospectively analyzed. Tumor samples from surgical specimen were collected and prepared for study in paraffin blocks. Results - Overall survival was 26.7 months in the HPT group and 62.4 months in the LTX group (P<0.01). Overall tumor recurrence was 66.7% in the HPT group (10/15) and 17% in the LTX group (8/47) (X²=13.602, P<0.01). Alpha-fetoprotein levels >200ng/mL, microvascular invasion and histological grade were associated with tumor recurrence (P<0.01). Recurrence rates in each surgical group and analysis of factors associated with tumor recurrence, when stratified for each genotypic pattern, were both not statistically significant. Conclusion - G/G genotype was not associated with tumor recurrence after surgical treatment and it did not show any correlation with other prognostic factors.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofArquivos de gastroenterologia. São Paulo. Vol. 52, n. 4 (out./nov. 2015), p. 325-330pt_BR
dc.rightsOpen Accessen
dc.subjectCarcinoma hepatocelularpt_BR
dc.subjectProto-oncogene proteins C-MDM2en
dc.subjectSingle-stranded conformational polymorphismen
dc.subjectPredisposição genética para doençapt_BR
dc.subjectHepatocellular carcinomaen
dc.subjectNeoplasias hepáticaspt_BR
dc.subjectIdoso de 80 anos ou maispt_BR
dc.subjectBiological tumor markersen
dc.subjectIntervalo livre de doençapt_BR
dc.titleAssociation between murine double minute 2 – T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatmentpt_BR
dc.title.alternativeAssociação entre o polimorfismo T309G – murine double minute 2 e a recorrência do carcinoma hepatocelular após o tratamento cirúrgico pt
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001070444pt_BR
dc.type.originNacionalpt_BR


Ficheros en el ítem

Thumbnail
   

Este ítem está licenciado en la Creative Commons License

Mostrar el registro sencillo del ítem