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dc.contributor.authorSausen, Tiago Rafaelpt_BR
dc.contributor.authorFialho, Sílvia Ligóriopt_BR
dc.contributor.authorBorges, Paulo Eduardo Mayorgapt_BR
dc.date.accessioned2018-09-26T02:33:57Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn0975-9344pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/182709pt_BR
dc.description.abstractThe purpose of this work was, applying experimental design methodology on tablet formulation development by direct compression, to evaluate the influences of magnesium stearate and sodium croscarmelose quantities upon clozapine tablets, by a Central Composite Design. The results were fitted to non-linear regression and a second order equation was used to plot response surface graphics. The results showed that hardness and friability were influenced by magnesium stearate quantities, decreasing the mechanical resistance of tablets, and the sodium croscarmelose quantities caused a linear decreased on disintegration time and a increased on dissolution efficiency of tablets, on the studied experimental field.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofInternational Journal of Drug Development and Research. London. Vol. 5, no. 3 (2013), p. 333-340pt_BR
dc.rightsOpen Accessen
dc.subjectCentral composite designen
dc.subjectClozapinapt_BR
dc.subjectEstatistica : Farmaciapt_BR
dc.subjectDirect compressionen
dc.subjectExperimental statistical designen
dc.titleDesign, optimization and evaluation of clozapine tablets by response surface analysispt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001075705pt_BR
dc.type.originEstrangeiropt_BR


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