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dc.contributor.authorLeão, Ari Ben-Hur Stefanipt_BR
dc.contributor.authorFerronato, Maria da Graçapt_BR
dc.contributor.authorKupski, Carlospt_BR
dc.contributor.authorSchacher, Fernando Comunellopt_BR
dc.contributor.authorMachado, Denise Cantarellipt_BR
dc.contributor.authorÁlvares-da-Silva, Mário Reispt_BR
dc.date.accessioned2018-09-18T02:30:21Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn2357-9730pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/182141pt_BR
dc.description.abstractMetabolism of iron is altered in patients infected with chronically Hepatitis C. The aim of this study is to compare compare the hepcidin levels in between individuais chronically infected with HCV and uninfected individuals. The aim of this study is to compare the hepcidin serum levels between individuals chronically infected with HCV and uninfected individuals. Methods: A cross-sectional study evaluating hepcidin serum levels of mono-infected HCV (n=29), naive, non-diabetic, non-cirrhotic and non-obese patients by means of ELISA, compared to uninfected patients (n=9) with the same characteristics. The degree of liver fibrosis, according to the METAVIR scale on liver biopsies, the lipid profile, the resistance insulin level, as calculated on HOMA-IR (homeostatic model assessment for insulin resistance), the interleukin-6 (IL-6) and the ferritin serum levels were also measured. Results: The levels of hepcidin were significantly lower in HCV patients compared to controls (8.4 pg/mL (±4.94) vs. 19.51 pg/mL (±5.51)) with p<0.001. The levels of ferritin and hepcidin did not show any relation. There was no difference between hepcidin levels in relation to viral genotype, viral load, IL-6 and degrees of fibrosis within HCV infected individuals. Conclusion: It is possible that hepatic iron overload in this population is explained by suppressed levels of hepcidin in patients with HCV.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofClinical and biomedical research. Porto Alegre. Vol. 38, n. 2 (2018), p. 105-110pt_BR
dc.rightsOpen Accessen
dc.subjectInterleucina-6pt_BR
dc.subjectHepcidinen
dc.subjectHCVen
dc.subjectHepatite Cpt_BR
dc.subjectInterleukin-6 (IL-6)en
dc.subjectHepcidinaspt_BR
dc.subjectMono-infecteden
dc.subjectFerropt_BR
dc.subjectCirrose hepáticapt_BR
dc.titleHepcidin serum levels in HCV chronically mono-infected naïve patients, compared to healthy individualspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001073586pt_BR
dc.type.originNacionalpt_BR


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