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dc.contributor.authorGazzoni, Guilherme Ferreirapt_BR
dc.contributor.authorFraga, Matheus Bompt_BR
dc.contributor.authorFerrari, Andrés Di Leonipt_BR
dc.contributor.authorSoliz, Pablo da Costapt_BR
dc.contributor.authorBorges, Anibal Pirespt_BR
dc.contributor.authorBartholomay, Eduardopt_BR
dc.contributor.authorKalil, Carlos Antonio Abunaderpt_BR
dc.contributor.authorGiaretta, Vanessapt_BR
dc.contributor.authorRohde, Luis Eduardo Paimpt_BR
dc.date.accessioned2018-07-31T02:33:30Zpt_BR
dc.date.issued2017pt_BR
dc.identifier.issn0066-782Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/180811pt_BR
dc.description.abstractBackground: Clinical studies demonstrate that up to 40% of patients do not respond to cardiac resynchronization therapy (CRT), thus, appropriate patient selection is critical to the success of CRT in heart failure. Objective: Evaluation of mortality predictors and response to CRT in the Brazilian scenario. Methods: Retrospective cohort study including patients submitted to CRT in a tertiary hospital in southern Brazil from 2008 to 2014. Survival was assessed through a database of the State Department of Health (RS). Predictors of echocardiographic response were evaluated using Poisson regression. Survival analysis was performed by Cox regression and Kaplan Meyer curves. A two-tailed p value less than 0.05 was considered statistically significant. Results: A total of 170 patients with an average follow-up of 1011 ± 632 days were included. The total mortality was 30%. The independent predictors of mortality were age (hazard ratio [HR] of 1.05, p = 0.027), previous acute myocardial infarction (AMI) (HR of 2.17, p = 0.049) and chronic obstructive pulmonary disease (COPD) (HR of 3.13, p = 0.015). The percentage of biventricular stimulation at 6 months was identified as protective factor of mortality ([HR] 0.97, p = 0.048). The independent predictors associated with the echocardiographic response were absence of mitral insufficiency, presence of left bundle branch block and percentage of biventricular stimulation. Conclusion: Mortality in patients submitted to CRT in a tertiary hospital was independently associated with age, presence of COPD and previous AMI. The percentage of biventricular pacing evaluated 6 months after resynchronizer implantation was independently associated with improved survival and echocardiographic response. (Arq Bras Cardiol. 2017; 109(6):569-578)en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofArquivos brasileiros de cardiologia. Vol. 109, n. 6 (dez. 2017), p. 569-578pt_BR
dc.rightsOpen Accessen
dc.subjectHeart failure / mortalityen
dc.subjectTerapia de ressincronização cardíacapt_BR
dc.subjectCardiac resynchronization therapyen
dc.subjectInsuficiência cardíacapt_BR
dc.subjectStroke volumeen
dc.subjectVolume sistólicopt_BR
dc.subjectBundle-branch blocken
dc.subjectBloqueio de ramopt_BR
dc.subjectCohort studiesen
dc.subjectMortalidadept_BR
dc.subjectEstudos de coortespt_BR
dc.subjectBrasilpt_BR
dc.titlePredictors of total mortality and echocardiographic response for cardiac resynchronization therapy : a cohort studypt_BR
dc.title.alternativePreditores de mortalidade total e de resposta ecocardiográfica à terapia de ressincronização cardíaca : um estudo de coortept
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001072963pt_BR
dc.type.originNacionalpt_BR


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