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Analysis of the epithelium-mesenchymal transition process on oral squamous cell carcinomas
dc.contributor.author | Lima, Taiane Berguemaier de | pt_BR |
dc.contributor.author | Klein, Isadora Peres | pt_BR |
dc.contributor.author | Oliveira, Márcia Gaiger de | pt_BR |
dc.contributor.author | Rados, Pantelis Varvaki | pt_BR |
dc.contributor.author | Sant'Ana Filho, Manoel | pt_BR |
dc.contributor.author | Visioli, Fernanda | pt_BR |
dc.date.accessioned | 2018-05-25T11:11:41Z | pt_BR |
dc.date.issued | 2017 | pt_BR |
dc.identifier.issn | 0103-6440 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/178815 | pt_BR |
dc.description.abstract | The aim of this study is to evaluate the immunohistochemical expression of E-cadherin, N-cadherin and Bmi-1, and their association with clinical parameters and with the degree of histopathological differentiation in oral squamous cell carcinomas. 65 squamous cell carcinoma samples were used for constructing a tissue microarray block, and then immunohistochemistry was performed for different markers. A semi-quantitative analysis of the amount of positive tumor cells was performed by two blind and calibrated observers (Kappa>0.75). The statistical Mann-Whitney and Kruskal-Wallis tests were used to evaluate the data. The correlation between variables was investigated by the Spearman test, and the significance level set at p<0.05. We observed higher expression of Bmi-1 in tumors located in the palate (p<0.0001). In addition, poorly differentiated tumors had a greater amount of Bmi-1 positive cells (p=0.0011). Regarding the other correlations between variables, no significant associations were detected. In conclusion, poorly differentiated squamous cell carcinomas located in the palate have higher immunostaining of Bmi-1, which can characterize activation of the Epithelial-Mesenchymal Transition process in these tumors. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Brazilian dental journal. Ribeirão Preto. Vol. 28, no. 5 (2017), p. 543-547 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Oral cancer | en |
dc.subject | Patologia bucal | pt_BR |
dc.subject | Neoplasias bucais | pt_BR |
dc.subject | Prognosis | en |
dc.subject | E-cadherin | en |
dc.subject | N-cadherin | en |
dc.subject | Bmi-1 | en |
dc.title | Analysis of the epithelium-mesenchymal transition process on oral squamous cell carcinomas | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001068368 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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