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dc.contributor.authorPfaffenseller, Biancapt_BR
dc.contributor.authorKapczinski, Flávio Pereirapt_BR
dc.contributor.authorGallitano, Amelia L.pt_BR
dc.contributor.authorKlamt, Fabiopt_BR
dc.date.accessioned2018-04-05T02:25:48Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn1662-5153pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/174424pt_BR
dc.description.abstractBipolar disorder (BD) is a severe psychiatric illness with a consistent genetic influence, involving complex interactions between numerous genes and environmental factors. Immediate early genes (IEGs) are activated in the brain in response to environmental stimuli, such as stress. The potential to translate environmental stimuli into long-term changes in brain has led to increased interest in a potential role for these genes influencing risk for psychiatric disorders. Our recent finding using network-based approach has shown that the regulatory unit of early growth response gene 3 (EGR3) of IEGs family was robustly repressed in postmortem prefrontal cortex of BD patients. As a central transcription factor, EGR3 regulates an array of target genes that mediate critical neurobiological processes such as synaptic plasticity, memory and cognition. Considering that EGR3 expression is induced by brain-derived neurotrophic factor (BDNF) that has been consistently related to BD pathophysiology, we suggest a link between BDNF and EGR3 and their potential role in BD. A growing body of data from our group and others has shown that peripheral BDNF levels are reduced during mood episodes and also with illness progression. In this same vein, BDNF has been proposed as an important growth factor in the impaired cellular resilience related to BD. Taken together with the fact that EGR3 regulates the expression of the neurotrophin receptor p75NTR and may also indirectly induce BDNF expression, here we propose a feed-forward gene regulatory network involving EGR3 and BDNF and its potential role in BD.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in behavioral neuroscience. Lausanne. Vol. 12 (Feb. 2018), article 15, [8] p.pt_BR
dc.rightsOpen Accessen
dc.subjectImmediate early genesen
dc.subjectTranstorno bipolarpt_BR
dc.subjectEarly growth response gene 3 (EGR3)en
dc.subjectGenes precocespt_BR
dc.subjectBrain-derived neurotrophic factor (BDNF)en
dc.subjectFator neurotrófico derivado do encéfalopt_BR
dc.subjectBipolar disorderen
dc.subjectPlasticidade neuronalpt_BR
dc.subjectNeuroplasticityen
dc.subjectRegulatory networken
dc.titleEGR3 immediate early gene and the brain-derived neurotrophic factor in bipolar disorderpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001063290pt_BR
dc.type.originEstrangeiropt_BR


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