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dc.contributor.authorFiorentini, Marlon Robertopt_BR
dc.contributor.authorSantos, Emanuel Burck dospt_BR
dc.contributor.authorLongo, Larissept_BR
dc.contributor.authorKliemann, Lucia Mariapt_BR
dc.contributor.authorKoff, Walter Josept_BR
dc.contributor.authorCorso, Carlos Otaviopt_BR
dc.date.accessioned2017-12-08T02:23:05Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn0102-8650pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/170962pt_BR
dc.description.abstractABSTRACTPURPOSE: To evaluate whether topical renal hypothermia (TRH) at different levels of temperature has protective effects on lung tissue after renal I/R, through an analysis of organ histology and inflammatory markers in lung tissue.METHODS: Twenty-eight male Wistar rats were randomly allocated across four groups and subjected to renal ischemia at different levels of topical renal temperature: normothermia (no cooling, 37°C), mild hypothermia (26°C), moderate hypothermia (15°C), and deep hypothermia (4°C). To induce I/R, the vessels supplying the left kidney of each animal were clamped for 40 minutes, followed by reperfusion. After four hours, another procedure was performed to harvest the tissues of interest. TNF-α, IL-1β and myeloperoxidase activity were measured in lung tissue. Histological analysis was performed in hematoxylin and eosin-stained lung specimens.RESULTS: Induction of renal I/R under deep topical hypothermia resulted in a significant decrease in lung concentrations of TNF-α compared with normothermic I/R (p<0.05). A trend toward significant correlation was found between lung IL-1β concentration and intensity of hypothermia (Spearman r=−0.37; p=0.055). No difference was found in myeloperoxidase activity or histologic injury between groups.CONCLUSION: Topical renal hypothermia reduces activation of the inflammatory cascade in the lung parenchyma. However, tissue-protective effects were not observed.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofActa cirúrgica brasileira. São Paulo, SP. vol. 30, n. 7 (jul. 2015), p. 445-451pt_BR
dc.rightsOpen Accessen
dc.subjectHypothermiaen
dc.subjectHipotermia induzidapt_BR
dc.subjectTemperatura baixapt_BR
dc.subjectIschemiaen
dc.subjectReperfusionen
dc.subjectTraumatismo por reperfusãopt_BR
dc.subjectRatos Wistarpt_BR
dc.subjectKidneyen
dc.subjectPulmãopt_BR
dc.subjectLungen
dc.subjectRatsen
dc.subjectRimpt_BR
dc.titleAnalysis of the effects of topical renal hypothermia on lung tissue after kidney ischemia and reperfusion in ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001027669pt_BR
dc.type.originNacionalpt_BR


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