Mostrar el registro sencillo del ítem

dc.contributor.advisorChies, Jose Artur Bogopt_BR
dc.contributor.authorCorrea, Julio Daimar Oliveirapt_BR
dc.date.accessioned2017-11-14T02:31:45Zpt_BR
dc.date.issued2016pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/170255pt_BR
dc.description.abstractMelanoma is a highly lethal skin cancer whose worldwide frequency increases every year. Metastatic melanoma is aggressive and resistant to conventional therapy. Cell adhesion molecules play a central role in cell-cell interactions, especially in metastasis and immunity. Among cell adhesion molecules, which are potential risk factors for melanoma, ICAM-1 was previously correlated with melanoma progression. This study aimed to verify the presence and frequency of the polymorphic variant rs5498 (-1548 A/G, K469E) of the ICAM1 gene in a sample of melanoma patients from southeastern Brazil. A total of 42 melanoma patients and 16 controls were genotyped and the frequencies of each variant were calculated. Our results indicate a frequency of 0.655 for the K allele in cases and of 0.719 for the control group. In our population, no correlation was identified between the rs5498 SNP and melanoma risk, although an increase in the sample size as well as the introduction of other variants of this and other adhesion molecules are needed in order to better establish the real role of such molecules in melanoma development and clinics.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.rightsOpen Accessen
dc.subjectMelanomapt_BR
dc.subjectMoléculas de adesão celularpt_BR
dc.titleAnalysis of the polymorphic variant rs5498 of ICAM-1 in melanoma patients from southeastern Brazilpt_BR
dc.typeTrabalho de conclusão de graduaçãopt_BR
dc.identifier.nrb001044226pt_BR
dc.degree.grantorUniversidade Federal do Rio Grande do Sulpt_BR
dc.degree.departmentInstituto de Biociênciaspt_BR
dc.degree.localPorto Alegre, BR-RSpt_BR
dc.degree.date2016pt_BR
dc.degree.graduationCiências Biológicas: Bachareladopt_BR
dc.degree.levelgraduaçãopt_BR


Ficheros en el ítem

Thumbnail
   

Este ítem está licenciado en la Creative Commons License

Mostrar el registro sencillo del ítem