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dc.contributor.authorCortegoso, Aurita Veronica Beovidept_BR
dc.contributor.authorLaureano, Natalia Koerichpt_BR
dc.contributor.authorSilva, Alessandra Dutra dapt_BR
dc.contributor.authorDanilevicz, Chris Krebspt_BR
dc.contributor.authorMagnusson, Alessandra Selingerpt_BR
dc.contributor.authorVisioli, Fernandapt_BR
dc.contributor.authorRados, Pantelis Varvakipt_BR
dc.date.accessioned2017-09-05T02:32:58Zpt_BR
dc.date.issued2017pt_BR
dc.identifier.issn1678-7757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/166179pt_BR
dc.description.abstractObjectives: To evaluate the number of AgNORs per nucleus and the expression of Ki-67 at the tumor invasion front (TIF) in relation to clinical parameters (TNM), TIF classification and the prognosis of oral squamous cell carcinomas in an Uruguayan population. Material and Methods: This study was conducted through a retrospective survey from 2000 to 2010 at the National Institute of Cancer Montevideo, Uruguay and included 40 patients. The samples were obtained from the resection of the tumor and the TIF was defined according with Bryne, et al.5 (1992). Expression of Ki-67 was assessed by the percentage of positive tumor cells and the AgNOR was recorded as the mean AgNOR (mAgNOR) and the percentage of AgNOR per nucleus (pAgNOR). All analyzes were performed by a blinded and calibrated observer. Results: No statiscally significant association was observed between immunostaining of Ki-67 and AgNOR with the different types of TIF, regional metastasis and patients prognosis, however it was observed an increase in Ki-67 expression associated with worse patient’s clinical staging, although not statistically significant. Conclusions: Our results suggest that proliferation markers as AgNOR and Ki-67 are not prognostic markers at the tumor invasive front of carcinoma of oral squamous cell.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofJournal of applied oral science. Bauru. Vol. 25, no. 3 (May/June 2017), p. 318-323pt_BR
dc.rightsOpen Accessen
dc.subjectCell proliferationen
dc.subjectCarcinoma de células escamosaspt_BR
dc.subjectOral canceren
dc.subjectProliferação celularpt_BR
dc.subjectNeoplasias bucaispt_BR
dc.subjectPatologia bucalpt_BR
dc.titleCell proliferation markers at the invasive tumor front of oral squamous cell carcinoma : comparative analysis in relation to clinicopathological parameters of patientspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001045545pt_BR
dc.type.originNacionalpt_BR


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