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dc.contributor.authorSouza, Ana Cláudia dept_BR
dc.contributor.authorSarria, Jairo Alberto Dussánpt_BR
dc.contributor.authorSouza, Andressa dept_BR
dc.contributor.authorCaumo, Wolneipt_BR
dc.contributor.authorTorres, Iraci Lucena da Silvapt_BR
dc.date.accessioned2017-05-30T02:37:07Zpt_BR
dc.date.issued2016pt_BR
dc.identifier.issn2357-9730pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/158723pt_BR
dc.description.abstractCaffeine consumption during pregnancy has been shown in the scientific literature to be associated with teratogenicity such as low birth weight, fetal malformations, and miscarriage. However, the morphological alterations of the offspring of dams exposed during pregnancy have not been consistently described, and the mechanisms why they occur remain elusive. Thus, we aimed to characterize the offspring malformations induced by moderate and high doses of caffeine during pregnancy. Dams were divided into three groups: control, moderate (0.3 g/L), and high dose (1.0 g/L) of caffeine, which was provided in the drinking water beginning on gestational day 1 and continuing throughout the entire gestation. At moderate doses, only one of the dams had stillborn pups, although no macroscopic malformations were observed. High doses of caffeine induced significantly more malformations (P<0.001) and early death (before P4). The malformations observed were related to fetal development and cardiovascular alterations, namely bruises, macrocephaly with short limbs, abnormal development (or absence) of head structures and limbs, labial malformations, hydrops fetalis, and poor placental formation. We discussed the proposed mechanisms by which caffeine might induce these phenotypes, which may involve down-regulation of adenosine A1 receptors, and increased mothers’ catecholamines. Our findings further confirm the evidence of the teratogenic effects of high doses of caffeine administered during pregnancy. These findings support the recommendation to avoid caffeine exposure during pregnancy.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofClinical and biomedical research. Porto Alegre. Vol. 36, n. 4, (2016), p. 179-186pt_BR
dc.rightsOpen Accessen
dc.subjectCaffeineen
dc.subjectCafeínapt_BR
dc.subjectOffspringen
dc.subjectGravidezpt_BR
dc.subjectTeratogenicityen
dc.subjectPregnancyen
dc.subjectHydropsen
dc.subjectCardiovascular alterationsen
dc.titleCaffeine teratogenicity in rats : morphological characterization and hypothesized mechanismspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001012675pt_BR
dc.type.originNacionalpt_BR


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