Blood transfusion-related immunomodulation

Vargas, Luciana do Nascimento; Garcia, Lais Oliveira; Galvão, Ananda Cristine Santos; Onsten, Tor Gunnar Hugo; Coitinho, Adriana Simon; Sekine, Leo

dc.contributor.author	Vargas, Luciana do Nascimento	pt_BR
dc.contributor.author	Garcia, Lais Oliveira	pt_BR
dc.contributor.author	Galvão, Ananda Cristine Santos	pt_BR
dc.contributor.author	Onsten, Tor Gunnar Hugo	pt_BR
dc.contributor.author	Coitinho, Adriana Simon	pt_BR
dc.contributor.author	Sekine, Leo	pt_BR
dc.date.accessioned	2017-05-24T02:26:26Z	pt_BR
dc.date.issued	2014	pt_BR
dc.identifier.issn	2357-9730	pt_BR
dc.identifier.uri	http://hdl.handle.net/10183/158440	pt_BR
dc.description.abstract	The phenomenon of transfusion-related immunomodulation (TRIM) has been studied since the observation of a higher kidney allograft survival in patients who had received a higher number of transfusions. Conversely, it has been suggested as one of the possible causes related to the development of infections in patients with multiple blood transfusions and/or after a major surgery, and has been also associated with a decreased function of natural killer cells (NK) and antigen-presenting cells (APCs), reduced cell-mediated immunity, and increased regulatory T cells (Tregs). This review aimed to conceptualize TRIM and discuss some aspects related to its mechanisms and the prevention of immunomodulatory events.	en
dc.format.mimetype	application/pdf	pt_BR
dc.language.iso	por	pt_BR
dc.relation.ispartof	Clinical and biomedical research. Vol. 34, no. 4 (2014), p. 333-341	pt_BR
dc.rights	Open Access	en
dc.subject	Immunomodulation	en
dc.subject	Imunomodulacao	pt_BR
dc.subject	Transfusão de sangue	pt_BR
dc.subject	Boold transfusion	en
dc.subject	Immunisuppression	en
dc.subject	Imunossupressão	pt_BR
dc.subject	Infecções	pt_BR
dc.subject	Infection	en
dc.subject	Leucócitos	pt_BR
dc.subject	Leukocytes	en
dc.title	Blood transfusion-related immunomodulation	pt_BR
dc.title.alternative	Imunomodulação relacionada à transfusão de hemocomponentes	pt
dc.type	Artigo de periódico	pt_BR
dc.identifier.nrb	000954948	pt_BR
dc.type.origin	Nacional	pt_BR

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