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dc.contributor.authorZugno, Alexandra Ioppipt_BR
dc.contributor.authorCanever, Larapt_BR
dc.contributor.authorChipindo, Helder, L.pt_BR
dc.contributor.authorMastella, Gustavo Antunespt_BR
dc.contributor.authorHeylmann, Alexandra S.pt_BR
dc.contributor.authorOliveira, Mariana B.pt_BR
dc.contributor.authorSteckert, Amanda Valnierpt_BR
dc.contributor.authorCastro, Adalberto A.pt_BR
dc.contributor.authorDal Pizzol, Felipept_BR
dc.contributor.authorQuevedo, João Luciano dept_BR
dc.contributor.authorGama, Clarissa Severinopt_BR
dc.date.accessioned2017-02-21T02:26:29Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn0001-3765pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/152814pt_BR
dc.description.abstractNew studies suggest that polyunsaturated fatty acids, such as omega-3, may reduce the symptoms of schizophrenia. The present study evaluated the preventive effect of omega-3 on interleukines (IL) and neurotrophin brain-derived neurotrophic factor (BDNF) levels in the brains of young rats subjected to a model of schizophrenia. Treatment was performed over 21 days, starting on the 30th day of rat’s life. After 14 days of treatment with omega-3 or vehicle, a concomitant treatment with saline or ketamine (25 mg/kg) was started and maintained until the last day of the experiment. BDNF levels in the rat’s prefrontal cortex were decreased at 1 h and 24 h after the last administration of ketamine, whereas the group administered with ketamine and omega-3 showed a decrease in BDNF levels only after 24 h. In contrast, both interventions induced similar responses in levels of IL-1β and IL6. These findings suggest that the similarity of IL-1β and IL6 levels in our experimental groups is due to the mechanism of action of ketamine on the immune system. More studies have to be carried out to explain this pathology. In conclusion, according to previous studies and considering the current study, we could suggest a prophylactic role of omega-3 against the outcome of symptoms associated with schizophrenia.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofAnais da Academia Brasileira de Ciências. Rio de Janeiro. Vol. 87, n. 2 supl (ago. 2015), p. 1475-1486pt_BR
dc.rightsOpen Accessen
dc.subjectEsquizofreniapt_BR
dc.subjectOmega-3en
dc.subjectKetamineen
dc.subjectÁcidos graxos ômega-3pt_BR
dc.subjectSchizophreniaen
dc.subjectKetaminapt_BR
dc.subjectNeurotrophinsen
dc.subjectInterleukinsen
dc.titleEffects of omega-3 supplementation on interleukin and neurotrophin levels in an animal model of schizophreniapt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001009845pt_BR
dc.type.originNacionalpt_BR


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