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dc.contributor.advisorGarcia, Cassia Virginiapt_BR
dc.contributor.authorGobetti, Carenpt_BR
dc.date.accessioned2017-02-21T02:26:23Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/152797pt_BR
dc.description.abstractTicagrelor is an orally active, reversibly binds of the P2Y12 receptor that can prevent ADP-mediated platelet activation and has a faster onset of action. A stability-indicating HPLC method for the determination of ticagrelor in coated tables was developed and validated. Chromatographic analysis were performed in a Shimadzu liquid chromatograph, equipped with Phemomenex® C18 column (250x4.6 mm, 5 μm), using a mobile phase composed of acetonitrile:water:triethylamine (57:43:0.5 v/v/v) pH 7.0, at 0.7 mL/min flow and injection volume of 20 μL. The proposed method was successfully applied to ticagrelor in coated tables, showing the method is useful for determination of the drug in routine analysis.en
dc.format.mimetypeapplication/pdf
dc.language.isoporpt_BR
dc.rightsOpen Accessen
dc.subjectTicagrelorpt_BR
dc.subjectTicagreloren
dc.subjectComprimidospt_BR
dc.subjectHPLCen
dc.subjectStability-indicating assayen
dc.subjectValidação : Métodos de análise de fármacospt_BR
dc.subjectControle de qualidade de medicamentospt_BR
dc.titleDesenvolvimento e validação de método por cromatografia para determinação de ticagrelor em comprimidos revestidospt_BR
dc.typeTrabalho de conclusão de graduaçãopt_BR
dc.contributor.advisor-coToigo, Rúbia Lazzaretti Pereirapt_BR
dc.identifier.nrb000905007pt_BR
dc.degree.grantorUniversidade Federal do Rio Grande do Sulpt_BR
dc.degree.departmentFaculdade de Farmáciapt_BR
dc.degree.localPorto Alegre, BR-RSpt_BR
dc.degree.date2013pt_BR
dc.degree.graduationFarmáciapt_BR
dc.degree.levelgraduaçãopt_BR


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